Advances in the role of disease-associated microglia in retinal ganglion cell injury in glaucoma

VernacularTitle:疾病相关小胶质细胞在青光眼视网膜神经节细胞损伤中的作用研究进展
Author: Ziyu QIU ¹ ; Pengfei CHEN ; Xi LIU ; Huaijin GUAN ; Min JI
Author Information

1. 226000 江苏省南通市,南通大学医学院
Publication Type:Journal Article
Keywords: glaucoma; disease associated microglia; retinal ganglion cells; nerve injury
From: Recent Advances in Ophthalmology 2025;45(7):578-582
CountryChina
Language:Chinese
Abstract: Glaucoma,characterized by optic nerve damage and progressive damage to retinal ganglion cells(RGCs),is the leading cause of irreversible blindness.However,the specific mechanism of RGC damage has not been fully elucida-ted.In recent years,there is increasing evidence that microglia,especially disease-associated microglia(DAM),may play an important role in glaucomatous ganglion cell injury.In this paper,we reviewed the role and mechanism of DAM in RGC damage in glaucoma,aiming to provide new insights for further research on the mechanism of RGC damage and subsequent protection of RGCs.