Research progress in relationship between polycystic ovary syndrome and ovarian follicle expansion and its regulatory mechanism
10.3969/j.issn.1671-7856.2025.03.012
- VernacularTitle:多囊卵巢综合征与卵泡扩张的关系及调控机制研究进展
- Author:
Yibo ZHANG
1
;
Li YANG
;
Shiguang FENG
;
Jie SUN
;
Xiaoqiong HAO
Author Information
1. 包头医学院生理学教研室,内蒙古包头 014040;包头医学院巴彦淖尔临床医学院,内蒙古包头 014040
- Publication Type:Journal Article
- Keywords:
ovarian follicle expansion;
follicular cavity formation;
follicular fluid accumulation;
granulosa cell proliferation;
polycystic ovary syndrome
- From:
Chinese Journal of Comparative Medicine
2025;35(3):137-146
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian follicle expansion is an important part of their growth and development into dominant follicles,and is regulated by a variety of molecules and signals,including follicular cavity formation,follicular fluid accumulation,and granulosa cell proliferation.Polycystic ovary syndrome(PCOS)is the most common reproductive endocrine disease in women,and patients mainly present with increased preantral follicles and polycystic ovarian lesions caused by inadequate ovarian follicle expansion.This review summarizes recent research developments concerning the physiological process of ovarian follicle expansion and the related regulatory factors and mechanisms.We also consider the possible factors restricting ovarian follicle expansion in patients with PCOS,to provide a theoretical basis for follicular dysplasia,ovulation disorders and other diseases caused by abnormal ovarian follicle expansion.
