Research progress in animal models of lung"inflammation-cancer"transformation
10.3969/j.issn.1671-7856.2025.03.011
- VernacularTitle:肺部"炎-癌"转化动物模型研究进展
- Author:
Yajuan CHEN
1
;
Lanying CHEN
;
Wenbin DUAN
;
Yuqing HUANG
;
Xuhui JIN
Author Information
1. 江西中医药大学,南昌 330004;中药固体制剂制造技术国家工程研究中心,南昌 330006;江西中医药大学中药药效物质基础江西省重点实验室(2024SSY07102),南昌 330004
- Publication Type:Journal Article
- Keywords:
"inflammation-cancer"transformation;
lung cancer;
animal models;
induction mechanisms;
advantages;
limitations
- From:
Chinese Journal of Comparative Medicine
2025;35(3):109-136
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is a serious pulmonary tumor,with exacerbation of chronic lung inflammation being a precursor to the development of lung cancer.Relevant animal models are widely used in experimental research,to gain a deeper understanding of the pathogenesis of lung cancer and to develop preventive treatment strategies.Induced lung cancer animal models are of particular importance for understanding the transition from chronic lung inflammation to lung cancer.Early intervention is crucial for the prevention and treatment of lung cancer.Here we review the recent literature regarding the inducing factors for lung cancer,including carcinogens(e.g.nicotine-derived nitrosamine ketone,benzopyrene,diethylnirtosamine atmospheric fine particulate matter(PM2.5),coal smoke,heavy metal ions,radiation,and biological infections).We also summarize animal models of lung inflammation and cancer transformation induced by these factors,discuss the mechanisms by which relevant carcinogens induce lung cancer,analyze the advantages and limitations of the animal models,and consider future development directions.This review aims is to provide a valuable reference for the future establishment of relevant models.
