Advances in pathological diagnosis and molecular characteristics of high-grade en-dometrial stromal sarcoma
10.13315/j.cnki.cjcep.2025.04.002
- VernacularTitle:高级别子宫内膜间质肉瘤的病理诊断及分子生物学研究进展
- Author:
Xiaohua SHI
1
Author Information
1. 中国医学科学院北京协和医学院北京协和医院病理科,北京 100730
- Publication Type:Journal Article
- Keywords:
high-grade endometrial stromal sarcoma;
gene rearrangement;
YWHAE-NUTM2A/2B;
ZC3H7B-BCOR;
BCOR ITD
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(4):427-431
- CountryChina
- Language:Chinese
-
Abstract:
High-grade endometrial stromal sarcoma(HGESS)is a rare but highly aggressive malignant tumor that poses a significant threat to women's reproductive health.It is associated with a poor clinical prognosis due to its high malignancy.HGESS exhibits diverse pathological morphologies,lacks specific immunohistochemical markers,and demonstrates various genetic alterations.These factors contribute to the challenges in achieving a definitive diagnosis,making accurate identification and diagnosis of this lesion particularly difficult.This article reviews the clinicopathologi-cal features,molecular characteristics,and key points for differential diagnosis of HGESS,aiming to enhance under-standing and awareness of this disease among clinicians and pathologists.
