Multi-target regulation of short-chain fatty acids in sepsis
10.3969/j.issn.1006-5725.2025.13.024
- VernacularTitle:短链脂肪酸多靶点调控脓毒症器官保护的研究进展
- Author:
Yunfen TIAN
1
;
Bin WANG
;
Fangxiang ZHANG
Author Information
1. 贵州医科大学麻醉学院(贵州 贵阳 550001)
- Publication Type:Journal Article
- Keywords:
sepsis;
short-chain fatty acids;
gut microbiota;
intestine-organ axis
- From:
The Journal of Practical Medicine
2025;41(13):2105-2110
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis,a systemic inflammatory disorder triggered by infection,is characterized by a complex pathophysiological mechanism that gives rise to high mortality rates and treatment bottlenecks.Short-Chain Fatty Acids(SCFAs),as the core metabolites of the intestinal flora,exhibit potential in organ protection during sepsis via a multi-target regulatory mechanism.In the realm of immunomodulation,SCFAs achieve a balance between pro-inflammatory and anti-inflammatory responses by activating G protein-coupled receptors,inhibiting the activation of NLRP3 inflammasomes,and suppressing the cascade reaction of pro-inflammatory factors.At the metabolic regu-lation level,SCFAs optimize mitochondrial function,mitigate the hypercatabolic state associated with sepsis,and relieve organ energy failure.Furthermore,SCFAs exert an organ-protective effect in multiple ways.They enhance the integrity of the intestinal barrier,inhibit pathogen translocation,and impede the systemic spread of inflammation through the synergistic mechanisms of the intestinal-organ axis.Animal and preclinical studies have demonstrated that exogenous supplementation of SCFAs or dietary fiber intervention may interact with the intestinal flora,offering a novel strategy for sepsis treatment.In this review,we systematically summarize the multi-target regulatory network of SCFAs in sepsis and the research progress regarding their organ-protective effects in sepsis.Additionally,we propose therapeutic strategies targeting microbial metabolites,thereby providing a new perspective for overcoming the limitations of traditional anti-infection and immunomodulation.
