Establishment of a nomogram model for comorbid cardiovascular disease in schizophrenia based on elec-trocardiogram parameters and kynurenine metabolites
10.3969/j.issn.1006-5725.2025.08.017
- VernacularTitle:基于心电图参数、犬尿氨酸代谢物建立精神分裂症共患心血管疾病的列线图模型
- Author:
Rui GUO
1
;
Tao LIU
;
Xi SU
Author Information
1. 新乡医学院第二附属医院(河南省精神病医院) 电生理科(河南 新乡 453002)
- Publication Type:Journal Article
- Keywords:
schizophrenia;
cardiovascular disease;
electrocardiogram;
kynurenine metabolites;
nomograph model
- From:
The Journal of Practical Medicine
2025;41(8):1205-1211
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the factors influencing comorbid cardiovascular disease in schizophrenia and to construct a column-line graphical model.Methods Clinical data of 586 schizophrenic patients in the hospi-tal from June 2023 to October 2024 were retrospectively collected.The study included 100 patients with comorbid cardiovascular disease and 486 patients without co-morbid cardiovascular disease,which were divided into the comorbidity group(n=100)and the non-comorbidity group(n=486).Propensity score matching(PSM)was used to reduce between-group bias.The clinical data,electrocardiogram parameters[QT corrected by heart rate(QTc),Tp-Te interval corrected by heart rate(TP-Tec)],and Kynurenine(KYN)metabolites[tryptophan(TRP),KYN,and kynurenic acid(KYNA)]were statistically analyzed in both groups.Logistic regression equation was used to screen the influencing factors of comorbid cardiovascular disease in schizophrenia.A nomogram model was constructed and validated.Results(1)BMI,smoking,alcohol consumption,sleep disorders,QTc,TP-Tec,TRP,KYN,and KYNA were all high-risk factors for co-morbid cardiovascular disease in schizophrenia(P<0.05).(2)The diagnostic AUC for the nomogram model was 0.876,and there was a good concordance between diagnostic and observational results;and the threshold probability of a net patient benefit was higher when the threshold probability was between 5%and 100%.Conclusion The nomogram model constructed based on QTc,TP-Tec,TRP,KYN,KYNA,etc.can help improve the diagnostic value of schizophrenia comorbid cardiovascular disease,guide clinical diagnosis and treatment,and reduce cardiovascular disease.
