The effects of epidermal growth factor on coordinated motor behaviors and nigrostriatal dopaminergic system in middle-aged rats
10.16557/j.cnki.1000-7547.2025.02.011
- VernacularTitle:表皮生长因子对中年大鼠协调运动及黑质-纹状体多巴胺系统的影响
- Author:
Yingyan HAO
1
;
Yuchuan JIN
;
Cuili CAO
;
Miaomiao JIA
;
Fengcang LIU
;
Yuanyuan TIAN
;
Yuan LI
Author Information
1. 唐山市工人医院重症医学科,唐山 063000
- Publication Type:Journal Article
- Keywords:
epidermal growth factor(EGF);
coordinated motor behavior;
nigrostriatal dopaminergic system;
aging;
rat
- From:
Chinese Journal of Neuroanatomy
2025;41(2):206-210,219
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of epidermal growth factor(EGF)on the coordinated motor behaviors and changes of nigrostriatal dopaminergic system under the impact of EGF in middle-aged rats.Methods:Healthy aged Sprague Dawley(SD)rats were subcutaneously administered EGF(0.1 mg/ml)in the dorsal region for 7 days.Adhe-sive removal test,tapered beam walking test and descending a wire mesh pole test were performed to detect the changes in the coordinated motor behaviors of rats as well as changes in the expression of tyrosine hydroxylase(TH)and dopa-mine transporter(DAT)of nigrostriatal dopaminergic system in rats.Results:Middle-aged rats showed reduced behav-ioral parameters of adhesive removal test,tapered beam walking test and descending a wire mesh pole test compared with those of adult rats(P<0.05),which were improved after treatment with EGF(P<0.05).The expression of TH and DAT in nigrostriatal dopaminergic system was down-regulated in middle-aged rats compared with that in adult rats(P<0.01),however,which were up-regulated after treatment with EGF(P<0.01).Conclusion:EGF can amelio-rate the decline in coordinated motor behaviors and increases the activity of nigrostriatal dopaminergic system in middle-aged rats.
