Prediction of Spontaneous Preterm Birth by Cervical Length at 16-24 Weeks in Twin Pregnancies
- VernacularTitle:双胎妊娠孕16～24周子宫颈长度对自发性早产的预测价值
- Author:
Qing HU
1
;
Hongyan LIU
1
;
Hua LIAO
1
;
Chunyan DENG
1
;
Haiyan YU
1
Author Information
1. 四川大学华西第二医院妇产科 出生缺陷与相关妇儿疾病教育部重点实验室,四川 成都 610041
- Publication Type:Journal Article
- Keywords:
Cervical length;
16-24 Gestational age;
Twin pregnancies;
Spontaneous preterm birth;
Ultrasonog-raphy
- From:
Journal of Practical Obstetrics and Gynecology
2025;41(4):319-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of cervical length(CL)measured at 16-24 weeks of ges-tation for spontaneous preterm birth in twin pregnancies.Methods:A retrospective study was conducted on 1001 twin pregnancy cases,including 569 cases in the spontaneous preterm birth group and 432 cases in the term birth group.Univariate and multivariate Logistic regression analyses were used to identify factors associated with spon-taneous preterm birth.The predictive value of CL for spontaneous preterm birth was analyzed by the receiver op-erating characteristic(ROC)curve.Results:At 16-24 weeks of pregnancy,the CL in the spontaneous preterm birth group(3.460±0.866 cm)was significantly shorter than that in the term birth group(3.711±0.589 cm),and the difference was statistically significant(P=0.005).There were statistically significant differences in the cervical fun-neling and its morphology between the term birth group and the spontaneous preterm birth group(P<0.05).Multivariate Logistic regression analysis showed that monochorionicity(aOR 0.161,95％ CI 0.074-0.351) and CL at 16-24 weeks of pregnancy(aOR 0.655,95％ CI 0.496-0.864) were influencing factors for spontaneous preterm birth(P <0.05).ROC curve analysis indicated that a CL cutoff of 3.045 cm at 16-24 weeks of pregnancy predicted spontaneous preterm birth before 34 weeks,with a sensitivity of 90.2％ ,specificity of 64.9％ ,and an area under the curve of 0.650.Conclusions:Measurement of CL at 16-24 weeks of pregnancy is a potential predictor of spontaneous preterm birth in twin pregnancies.In addition,when establishing a prediction model for spontaneous preterm birth,future research should also consider cervical funnel morphology.
