The role and mechanisms of the RhoA/ROCK signaling pathway in acute pancreatitis:research progress
10.7659/j.issn.1005-6947.240649
- VernacularTitle:RhoA/ROCK信号通路在急性胰腺炎中的作用机制研究进展
- Author:
Huan LEI
1
;
Xin XIA
;
Zhiyu LIN
;
Tao WANG
Author Information
1. 川北医学院临床医学院,四川 南充 637000;中国人民解放军西部战区总医院 普通外科中心,四川 成都 610083
- Publication Type:Journal Article
- Keywords:
Pancreatitis;
RhoA/ROCK Pathway;
Microcirculation;
Inflammation;
Review
- From:
Chinese Journal of General Surgery
2025;34(3):563-571
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis(AP)is a severe digestive system emergency characterized by high morbidity and mortality,with a complex pathogenesis involving multiple signaling pathways.Among them,the RhoA/ROCK signaling pathway plays a crucial role in the onset and progression of AP,influencing pancreatic inflammation,fibrosis,microcirculatory regulation,and interactions with other signaling pathways.Studies have shown that inhibiting the RhoA/ROCK signaling pathway can effectively alleviate AP severity,reduce inflammatory cytokine levels,and improve pancreatic microcirculation,offering new therapeutic insights and potential strategies for AP treatment.Therefore,this review systematically summarizes the structure and function of the RhoA/ROCK signaling pathway,explores its mechanistic role in AP progression,and further discusses its potential clinical applications.By integrating existing research findings,this paper aims to provide new perspectives on the role of this signaling pathway in AP and offer a theoretical foundation for future basic research and clinical applications.
