Detection and clinical significance of serum FGF23 and 25-OH-VD levels in children with osteoporosis
10.3760/cma.j.cn115807-20241018-00323
- VernacularTitle:儿童骨质疏松症血清FGF23、25-OH-VD水平检测及临床意义
- Author:
Nuan HAN
1
;
Wenke CHEN
1
;
Sainan WANG
1
;
Tao LI
1
;
Tixue WANG
1
;
Jinsong SUN
1
Author Information
1. 济宁医学院附属医院小儿外科，济宁 272100
- Publication Type:Journal Article
- Keywords:
Osteoporosis;
Children;
Fibroblast growth factor 23;
25-hydroxyvitamin;
Recurrence
- From:
Chinese Journal of Endocrine Surgery
2025;19(4):579-583
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship among serum levels of fibroblast growth factor 23 (FGF23), 25-hydroxyvitamin D (25-OH-VD) and osteoporosis in children.Methods:Eighty children with osteoporosis admitted to Affiliated Hosptial of Jining Medieal University from Jun. 2019 to Jun. 2024 were included as the observation group, and 60 healthy children who underwent physical examination during the same period were included as the control group. Serum FGF23 and 25-OH-VD levels were compared between the two groups, and bone mineral density and bone metabolism indexes [CTX-1, osteocalcin (OC) and N-terminal propeptide of type I precollagen (PINP) ] were detected. Pearson correlation was used to analyze the correlation among serum FGF23, 25-OH-VD, bone metabolism indexes and bone mineral density. Logistic regression model was used to analyze the risk factors of osteoporosis in children.Results:Serum FGF23 and CTX-1 levels in the observation group were significantly higher than those in the control group ( t=15.77, 7.56, P < 0.05), while serum 25-OH-VD, OC, PINP and BMD levels were significantly lower ( t=14.09, 2.70, 13.25, 3.63, P < 0.05) ; Pearson correlation analysis showed that BMD was not correlated with age, BMI and OC ( r=-0.07, -0.02, 0.01, P > 0.05), BMD was negatively correlated with FGF23 and CTX-1, and positively correlated with 25-OH-VD and PINP ( r=-0.35, -0.34, 0.41, 0.40, P < 0.05). The stepwise regression model showed that FGF23 and 25-OH-VD were the main factors affecting BMD ( t=-2.40, 9.02, P<0.05). Multifactor Logistic regression model showed that FGF23 and 25-OH-VD were related factors of osteoporosis in children ( OR=3.01,1.16, P<0.05) . Conclusion:Serum FGF23 level is higher and 25-OH-VD level is lower in children with osteoporosis, which is significantly correlated with bone mineral density and is a related factor for osteoporosis in children.
