Relationship between clinical phenotype and fluid balance in sepsis patients based on latent profile analysis
10.3760/cma.j.cn211501-20240910-02471
- VernacularTitle:基于潜在剖面分析脓毒血症患者临床表型与液体平衡的关系
- Author:
Min DENG
1
Author Information
1. 广州市红十字会医院重症医学科，广州 510200
- Publication Type:Journal Article
- Keywords:
Sepsis;
Phenotype;
Fluid balance;
Latent profile analysis
- From:
Chinese Journal of Practical Nursing
2025;41(26):2052-2058
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To identify clinical phenotypes of sepsis patients by potential profile analysis, and further to explore the association between fluid balance and in-hospital mortality in sepsis patients with different phenotypes, to provide a basis for individualized liquid management.Methods:By a retrospective analysis method, clinical data of sepsis patients from February 2022 to February 2024 at Guangzhou Red Cross Hospital were collected by purposive sampling. The phenotypes of sepsis was identified by latent profile analysis, multivariable Logistic regression model was implemented to explore the association between fluid balance and in-hospital mortality in sepsis patients with different clinical phenotypes.Results:Total of 215 sepsis patients were included in the present study, 137 males and 78 females, aged 40-85 (62.26 ± 12.41) years. 215 patients including basic type 117 cases accounted for 54.4%, mortality risk type 42 cases accounted for 19.5%, renal failure type 56 cases accounted for 26.1%. Sequential Organ Failure Assessment scores ( OR = 3.085, 95% CI 1.842-5.167), hospitalization duration ( OR = 1.671, 95% CI 1.259-2.217), in-hospital mortality ( OR = 0.149, 95% CI 0.031-0.725) was the risk factor for mortality risk type; creatinine ( OR = 1.131, 95% CI 1.059-1.208), urine output ( OR = 0.995, 95% CI 0.890-0.997), continuous renal replacement therapy ( OR = 3.266, 95% CI 1.505-6.906) was the risk factor for renal failure type. As the increased of 3 days accumulated fluid balance, the risk of in-hospital mortality was decreased in the mortality risk type ( OR = 0.733, 95% CI 0.558-0.962), the risk of in-hospital mortality was increased in the renal failure type ( OR = 1.787, 95% CI 1.226-2.605). Conclusions:Sepsis patients clinical phenotypes can divide into basic type, mortality risk type and renal failure type, which demonstrate different characteristics and influence factors, and the correlation between fluid balance and in-hospital mortality also differs across them.
