Mixed Cardiac Amyloidosis:a Case Report and Literature Review
10.3969/j.issn.1000-3614.2025.04.011
- VernacularTitle:混合型心肌淀粉样变一例及文献回顾
- Author:
Xinghui SHAO
1
;
Jing YAO
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 心内科,北京 100037
- Publication Type:Journal Article
- Keywords:
cardiac amyloidosis;
light chain transthyretin amyloidosis;
transthyretin amyoldosis;
endomyocardial biopsy
- From:
Chinese Circulation Journal
2025;40(4):388-391
- CountryChina
- Language:Chinese
-
Abstract:
We report a rare case of mixed cardiac amyloidosis.The patient was a 66-year-old woman who suffered from recurrent syncope and hypertrophic cardiomyopathy was diagnosed.As the disease progresses,multiple systems are involved.Finally,AL-λ and transthyretin amylodosis(ATTR)mixed cardiac amyloidosis was confirmed by endocardial myocardial biopsy,mainly AL-λ type.This article reviews the clinical manifestations,diagnostic methods,and therapeutic modalities of cardiac amyloidosis,and discusses the rarity of mixed amyloidosis and its diagnostic challenges.This case suggests that clinicians should remain vigilant in considering the possibility of amyloidosis when dealing with patients with progressive heart failure and cardiac hypertrophy,and highlights the importance of endocardial myocardial biopsy in the diagnosis of cardiac amyloidosis in suspected patients.
