Pathological processes,inflammatory responses,and related biomarkers of periodontitis:a multi-omics analysis
10.12307/2025.988
- VernacularTitle:牙周炎的病理过程、炎症反应及相关生物标志物:多组学分析
- Author:
Yixuan ZHANG
1
;
Dongna LI
;
Chunyan LIU
Author Information
1. 河北医科大学口腔医(学)院正畸科
- Publication Type:Journal Article
- Keywords:
omics;
periodontitis;
transcriptomics;
proteomics;
metabolomics;
genomics;
multi-omics;
diagnostic biomarkers;
inflammation
- From:
Chinese Journal of Tissue Engineering Research
2025;29(35):7601-7610
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:In recent years,the rapid development of omics technologies has ushered oral medicine research into a new era.The extensive application of these technologies not only systematically reveals the complexity and dynamic changes within biological systems but also provides a comprehensive perspective for studying various diseases,including periodontitis.OBJECTIVE:To review the recent advancements in the application of omics technologies in periodontitis research,while also addressing existing challenges,thereby expanding the scope for the prevention and treatment of periodontitis and its applications in other clinical fields.METHODS:A literature search was conducted on PubMed and CNKI databases,covering publications from June 1993 to August 2024.The search terms included"omics,""periodontitis,""transcriptomics and periodontitis,""proteomics and periodontitis,""genomics and periodontitis,""metabolomics and periodontitis"and"multi-omics and periodontitis"in English and Chinese,respectively.A total of 72 relevant articles were included for further analysis.RESULTS AND CONCLUSION:(1)By using genomics,transcriptomics,proteomics,and metabolomics,researchers can conduct in-depth analyses of pathological processes,inflammatory responses,and associated biomarkers of periodontitis from multiple dimensions.(2)Recent studies have indicated that omics technologies can identify key genes and metabolites and other factors associated with periodontitis,facilitating a precise understanding and intervention of the disease.As these technologies continue to advance,omics analysis will be more widely applied in periodontitis research,driving the development of more effective preventive and therapeutic strategies,thereby improving patients'quality of life.
