Bidirectional Mendelian Randomization of the Association Between Anxiety Disorders and Cardiovascular Disease Risk
10.3870/j.issn.1672-0741.24.08.021
- VernacularTitle:焦虑症与心血管疾病风险关联的双向孟德尔随机化研究
- Author:
Wenjuan ZHU
1
;
Ruining XU
;
Ying YANG
Author Information
1. 东南大学公共卫生学院流行病与卫生统计学系,南京 210009
- Publication Type:Journal Article
- Keywords:
anxiety disorder;
cardiovascular disease;
Mendelian randomization;
causality
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(2):217-222,227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the causal relationships between anxiety disorders and coronary heart disease(CHD),atrial fibrillation(AF),heart failure(HF),stroke and myocardial infarction(MI)risks by using the bidirectional two-sample Mendelian randomization study method.Methods The data were collected from the genome-wide association study(GWAS)conducted within the population-based Danish Lundbeck Foundation Initiative for Integrative Psychiatric Research(iPSYCH)study,as well as from five other databases related to cardiovascular diseases.The inverse variance weighting(IVW)method was used to produce the main results,and four methods,including MR-Egger regression,weighted median method,weighted model,and simple model,supplemented the results.Sensitivity analyses such as heterogeneity,horizontal pleiotropy,and leave-one-out analysis were also performed.Results The IVW and MR-Egger regression showed that anxiety disorders would increase the risk of coronary heart disease(IVW:OR=1.0001,95％CI=1.0001-1.0025,P=0.040;MR-Egger:OR=1.0030,95％CI=1.0009-1.0058,P=0.013).There was no evidence of a causal effect of cardiovascular diseases on anxiety disorders risks.There was no horizontal pleiotropy and heterogeneity in the instrumental variables of this study.The result of sensitivity analysis was robust.Conclusion The study supports the causal effect of anxiety disorders on CHD risk,but no association is found with an increased risk of other cardiovascular diseases,such as AF,HF,stroke,and MI.No reverse causal association effect is observed.
