Construction of a comprehensive nursing evaluation indicator system for CAR-T cell therapy of HIV infected patients with hematologic neoplasm
10.3760/cma.j.cn211501-20241009-02755
- VernacularTitle:HIV感染合并血液系统恶性肿瘤患者CAR-T治疗全程护理评价指标体系的构建
- Author:
Ying HUANG
1
;
Huafen WANG
;
Danping SUN
;
Lifang SHAO
;
Xiaoyu ZHOU
Author Information
1. 浙江大学医学院附属第一医院感染科，杭州 310003
- Publication Type:Journal Article
- Keywords:
HIV;
Hematologic neoplasms;
Immunotherapy;
Nursing care;
Chimeric antigen receptor
- From:
Chinese Journal of Practical Nursing
2025;41(30):2328-2335
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To construct a comprehensive nursing evaluation indicator system for HIV infected patients with hematological malignancies receiving chimeric antigen receptor T cell therapy, and provide theoretical support for clinical nursing practice.Methods:From November 2023 to February 2024, the first draft of indicator system was developed through literature review and panel meeting, experts from 6 provinces and cities were interviewed by Delphi consultations, and the final draft were formed by revision.Results:A total of 18 experts took part in the expert consultation, included 4 males and 14 females, aged (44.00 ± 7.24) years. The effective recovery rates of questionnaire for both rounds were 18/18, and the authority coefficient were 0.894 and 0.900, respectively. The coordination coefficients of the third level items were 0.146 and 0.128 respectively (both P<0.05) regarding the importance, and 0.156 ( P<0.05) regarding the operability. The final comprehensive nursing evaluation indicator system for HIV infected patients with hematological malignancies receiving chimeric antigen receptor T cell therapy consisted of 5 first-level items, 28 second-level items and 89 third-level items. Conclusions:The comprehensive nursing evaluation indicator system of CAR-T therapy for HIV infected patients with hematological malignancies is scientific, reliable and comprehensive, which can provide reference for clinical nurses in nursing practice and training related to CAR-T and AIDS.
