Value of dual-energy CT parameters in evaluating the pathological grade of pancreatic ductal adenocarcinoma
10.3760/cma.j.cn.115807-20231030-00126
- VernacularTitle:双能量CT参数对胰腺导管腺癌病理分级的评估价值
- Author:
Dan XIE
1
;
Hongwei LIANG
;
Yang ZHOU
;
Hao WU
;
Ruike ZHANG
;
Chuanming LI
;
Yongmei LI
Author Information
1. 重庆医科大学附属第一医院放射科，重庆 400016
- Publication Type:Journal Article
- Keywords:
Pancreatic ductal adenocarcinoma;
Dual-energy CT;
Iodine maps;
Fat fraction
- From:
Chinese Journal of Endocrine Surgery
2025;19(2):266-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the value of dual-energy CT parameters in the evaluation of pathological grade of pancreatic ductal adenocarcinoma.Methods:80 cases of pancreatic ductal adenocarcinoma confirmed by pathology were retrospectively analyzed and divided into high grade group (36 cases) and low grade group (44 cases) according to their differentiation degree. All 80 patients underwent SOMATOM Force DECT for arterial phase (AP) and pancreatic phase (PP) scanning, and measured dual-energy parameters including dual-phase iodine concentration (IC AP, IC PP) in tumors and normal pancreatic parenchyma, pancreatic phase and arterial phase iodine concentration difference (ICD PP-AP) in tumors, dual-phase iodine uptake ratio (IUR AP, IUR PP) , dual-phase tumor/normal pancreatic parenchyma fat fraction ratio, and dual-phase slope of energy spectrum curve. Differences between two groups were compared by two independent sample t-test or Mann-Whitney U test or chi-square test. The multivariate logistic regression model was used to analyze the influencing factors of pathological grading of PDAC. Results:There were statistically significant differences in gender, age, aspect ratio, positive lymph node, fat fraction ratio in pancreatic phase between the two groups ( P< 0.05) . The multivariate logistic regression analysis showed that fat fraction ratio in pancreatic phase ( OR=1.781, 95% CI 1.127-2.814, P=0.013) , positive lymph node ( OR=4.870, 95% CI 1.488-15.938, P=0.009) , aspect ratio ( OR=0.019, 95% CI 0.001-0.437, P=0.013) were independent factors influencing the pathologic grade of PDAC. Conclusion:Parameters of dual-energy CT are valuable in the evaluation of pathological grading of PDAC.
