The study on the circulation inflammatory biomarkers in prediction in critical limb ischemia of patients with type 2 diabetes
10.13431/j.cnki.immunol.j.20250008
- VernacularTitle:血管内皮细胞炎性循环生物标志物预测糖尿病重症肢体缺血的临床研究
- Author:
Jingrong NIU
1
;
Chunmin LI
1
Author Information
1. 100020 北京,首都医科大学附属北京朝阳医院血管外科
- Publication Type:Journal Article
- Keywords:
Endothelial dysfunction of blood vessels;
Critical limb ischemia;
Diabetes foot ulcer
- From:
Immunological Journal
2025;41(1):59-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the potential immune biomarkers of critical limb ischemia(CLI)in patients with diabetes.Methods From January 2018 to December 2023,102 patients who were definitely diagnosed as CLI and diabetes foot ulcers(DFU)requiring percutaneous transluminal angioplasty and foot surgery were enrolled.Serum levels of 18 cellular immune and inflammatory factors including soluble CD40 ligand(sCD40L),IFN-α,IFN-γ,IL-2,IL-4,IL-6,IL-8,IL-10,IL-13,IL-18,et cetera,were measured in these patients.Results The levels of circulating serum sICAM-1 and endothelin-1 showed a negative correlation with the recovery of DFU.Moreover,PAI-1 and endothelin-1 were related to the demand for neovascular reconstruction.The circulating serum levels of thrombomodulin and sCD40L were associated with new and recurrent lesions.Conclusion The level of circulating biomarkers related to the immunity of vascular endothelial cell can be used to predict the risk of new or recurrent CLI in patients with diabetes.
