Research Progress on the Mechanism of Mitochondrial Biogenesis in Cerebral Ischemia-Reperfusion Injury
10.3870/j.issn.1672-0741.24.08.013
- VernacularTitle:线粒体生物发生在脑缺血再灌注损伤中作用的研究进展
- Author:
Jingjing LI
1
;
Ruiqing LI
;
Jianyun ZHANG
Author Information
1. 河南中医药大学康复医学院,郑州 450046;河南中医药大学第一附属医院康复中心,郑州 450000
- Publication Type:Journal Article
- Keywords:
cerebral ischemia-reperfusion injury;
mitochondrial biogenesis;
ischemic stroke;
PGC-1α;
SIRT1
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(2):298-304
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke(IS)is an acute cerebrovascular disease caused by sudden obstruction or occlusion of cerebral blood vessels,and is one of the major causes of disability and death in China.The main therapeutic goal is to restore blood flow as soon as possible after the onset of symptoms,and intravenous thrombolysis and endovascular thrombectomy are often adopted.However,post-thrombolysis blood recirculation is prone to lead to cerebral ischemia-reperfusion injury(CIRI).CIRI is a key pathological process in IS,so it is critical to find ways to mitigate CIRI.Mitochondrial biogenesis(MB)coordinates synthe-sis of new mitochondria from existing ones.When cerebral ischemia occurs,the body maintains mitochondrial homeostasis by ac-tivating MB,alleviates oxidative stress and inflammatory response,and prevents the body from further damage.Understanding the molecular mechanism of MB and its activation pathway will provide a new direction for the treatment of CIRI.This review summarizes the molecular mechanism of MB,the protective mechanism of MB for CIRI by maintaining mitochondrial homeosta-sis,inhibiting oxidative stress and inflammation after IS,and the potential therapeutic targets to improve CIRI by activating MB.It will provide new ideas for clinical treatment of CIRI.
