Advances in the Genetic Research of Non-syndromic Thoracic Aortic Aneurysm or Aortic Dissection
10.3969/j.issn.1000-3614.2025.04.015
- VernacularTitle:非综合征型胸主动脉瘤/主动脉夹层的基因学研究进展
- Author:
Yidan TIAN
1
;
Aihua ZHI
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院 放射影像科,北京 100037
- Publication Type:Journal Article
- Keywords:
thoracic aortic aneurysm;
aortic dissection;
gene screening;
genotype
- From:
Chinese Circulation Journal
2025;40(4):406-410
- CountryChina
- Language:Chinese
-
Abstract:
Non-syndromic thoracic aortic aneurysm or aortic dissection(TAAD)is a cardiovascular disease with high lethality rate.Researches have indicated that TAAD has a definite genetic basis.Genetic mutations play a crucial role in the disease's development and are associated with the age of onset,clinical symptoms,and the risk of aortic dissection.The rate of disease progression and the therapeutic response of individuals may vary depending on the type of mutation.Genetic screening is a crucial tool for identifying high-risk populations,which provides a scientific basis for early disease intervention and management and facilitates the implementation of precision medicine.In this article,we present a systematic review of the latest advancements in the research on gene mutations associated with non-syndromic TAAD.
