Value of ultrasound-guided core needle biopsy combined with serum HER2 and ER detection in the diagnosis of ductal carcinoma in situ
10.3760/cma.j.cn115807-20250124-00039
- VernacularTitle:超声引导下真空辅助活检联合血清HER2、ER检测对乳腺导管原位癌的诊断价值
- Author:
Weida CHEN
1
;
Zhongdaoyuan REN
1
;
Quanqiang GAO
1
Author Information
1. 浙江省海宁市人民医院普外科，海宁 314400
- Publication Type:Journal Article
- Keywords:
Ductal carcinoma in situ;
Invasive carcinoma;
Core needle biopsy;
Epidermal growth factor 2;
Estrogen receptor
- From:
Chinese Journal of Endocrine Surgery
2025;19(2):167-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the diagnostic value of ultrasound-guided core needle biopsy (CNB) combined with serum epidermal growth factor 2 (HER2) and estrogen receptor (ER) in ductal carcinoma in situ (DCIS) .Methods:50 patients diagnosed with DCIS before and after surgery admitted to Department of General Surgery, Haining People’s Hospital, Zhejiang Province from Sep. 2022 to Feb. 2024 were retrospectively included as the DCIS group. Another 50 DCIS patients with postoperative pathological upgrade to invasive ductal carcinoma (IDC) were selected as the control group. All patients underwent ultrasound-guided CNB before surgery, and serum HER2 and ER levels were detected. The value of lesion pathological features combined with serum HER2 and ER detection in the diagnosis of simple DCIS was analyzed by receiver operating characteristic curve (ROC) .Results:The low and intermediate nuclear grade, no calcification and the proportion of negative HER-2 and Ki67 expression in DCIS group was lower than that in control group (χ 2=16.98, 13.50, 4.24, 5.47, P<0.05) . Serum HER2 level in DCIS group was lower than that in control group, while serum ER level was higher ( t value = 34.40, 34.02, all P<0.05) . ROC results showed that the area under the curve (AUC) of low and intermediate nuclear grade, no calcification, negative Ki67 expression, serum HER2, and ER levels were 0.660, 0.660, 0.720, 0.752, 0.810 and 0.777, respectively; The AUC of the combined diagnosis of DCIS was 0.864, and the sensitivity and specificity were 84.00% and 86.00% (all P<0.05) . Conclusion:Ultrasound-guided CNB combined with serum HER2 and ER has high diagnostic efficiency in DCIS.
