Research Progress of Endothelial Mechanoreceptors in Aortic Dilation Disease
10.16156/j.1004-7220.2025.02.033
- VernacularTitle:内皮细胞力学感受器在主动脉扩张疾病中的研究进展
- Author:
Rong ZHAO
1
;
Huiying SUN
1
;
Shuangshuang LI
1
;
Qingsheng LU
1
Author Information
1. 海军军医大学第一附属医院 血管外科,上海 200240
- Publication Type:Journal Article
- Keywords:
aortic dilation diseases;
endothelial cells;
mechanoreceptors;
vascular biomechanics;
hemodynamics;
mechanical stress
- From:
Journal of Medical Biomechanics
2025;40(2):492-498
- CountryChina
- Language:Chinese
-
Abstract:
The hemodynamics within the aortic lumen is highly complex,and the mechanical stimuli generated by blood flow play a crucial role in the occurrence and progression of aortic dilation disease.Endothelial cells,as key components of the vascular endothelium,respond precisely to microenvironmental changes caused by blood flow through mechanoreceptors,including ion channels,receptor tyrosine kinases,and membrane structures.These mechanoreceptors convert mechanical stresses into biochemical signals,thereby affecting the physiological functions and pathological changes of blood vessels.In recent years,significant advances have been made in understanding the mechanisms by which endothelial mechanoreceptors are involved in aortic dilation diseases.This review summarizes the research progress of mechanoreceptor-mediated endothelial cell function in regulating aortic dilation diseases and provides a perspective on future research directions,with the aim of offering new insights and potential targets for the development of clinical treatment strategies.
