Electroacupuncture Alleviates Hepatic Lipid Accumulation and Intestinal Mucosal Injury in Hyperlipidemia Model Rats
10.3870/j.issn.1672-0741.24.07.003
- VernacularTitle:电针干预缓解高脂血症模型大鼠肝脏脂质积累和肠黏膜损伤
- Author:
Huan WU
1
;
Zhaoqing ZHANG
;
Shiru JU
Author Information
1. 江汉大学医学部中医学院/江汉大学针灸研究所,武汉 430056;武汉市第三医院疼痛康复科,武汉 430074
- Publication Type:Journal Article
- Keywords:
hyperlipemia;
electroacupuncture;
FXR/FGF19 pathway;
intestinal barrier
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(2):166-171
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of electrotherapy on liver and intestinal mucosal injury in hyperlipidemia rats.Methods Wistar rats were divided into control group,model group and electroacupuncture group,with 6 rats in each group.Both the model group and the electroacupuncture group were fed with high-fat diet,and the electroacupuncture group re-ceived electroacupuncture intervention.After treatment,HE staining was used to detect the pathological changes of liver and ile-al mucosa.The contents of TC,TG,LDL-C and HDL-C in serum of rats were detected by biochemical method.AB-PAS staining was used to detect ileum mucosa in rats.The protein expressions of FXR,FGF19,ZO-1,occludin and JAM-C in rat ileum were detected by Western blotting.Results Compared with the control group,the body weight was significantly increased in the model group(P＜0.05),and the liver and ileum tissues were seriously damaged.The levels of TC,TG and LDL-C in serum and the expression of JAM-C protein in ileum were increased(P＜0.01).HDL-C level in serum,FXR,FGF19,ZO-1 and occludin in ileum tissue were decreased(P＜0.01).Compared with model group,the weight gain of rats in electroacupuncture group was significantly reduced(P＜0.01),and the pathological injury of liver and ileum tissue was alleviated.The levels of TC,TG and LDL-C in serum and the expression of JAM-C protein in ileum were decreased(P＜0.01).HDL-C level in serum as well as FXR,FGF19,ZO-1 and occludin levels in ileum tissue were increased(P＜0.01).Conclusion Electroacupuncture stimulation can improve the damage of intestinal barrier by activating FXR/FGF19 pathway in rats,play a protective role in liver,and inhibit dyslipidemia.
