Advances in signaling pathways associated with androgenetic alopecia
- VernacularTitle:雄激素性脱发相关信号通路的研究进展
- Author:
Zhongyi TANG
1
;
Zhiwei HU
1
;
Wangge LI
1
;
Peiqiang LIU
1
;
Mingyang FANG
1
;
Jie ZHONG
1
;
Ziwei XI
1
;
Lei GUO
1
Author Information
- Publication Type:Journal Article
- Keywords: Androgenetic alopecia; Signaling pathways; Cytokines; Hair growth
- From: Chinese Journal of Endocrine Surgery 2024;18(6):914-916
- CountryChina
- Language:Chinese
- Abstract: Androgenetic alopecia (AGA) is currently the most common hair loss disease, which is the result of a combination of genetic and environmental factors, and manifests itself as miniaturization of hair follicles around the top of the head and frontotemporal region, which eventually leads to hair reduction or disappearance. The pathogenesis of AGA is closely related to a variety of signaling pathways, which include the Wnt/β-catenin signaling pathway, bone-forming protein (BMP) signaling pathway, insulin-like growth factor (IGF) signaling pathway, fibroblast growth factor (FGF) signaling pathway, hedgehog (SHH) signaling pathway, and so on. Several cytokines are involved in these signaling pathways, including β-catenin, BMP2, IGF-1, and FGF5. An in-depth study of AGA-related signaling pathways and related cytokines can help to provide a comprehensive understanding of the pathogenesis of AGA, provide a certain theoretical basis for the discovery of new signaling pathways, and provide a new research direction for the treatment of AGA.
