Research progress on magnetic resonance imaging and neurobiological mechanisms of anhedonia in major depressive disorder
10.3969/j.issn.1002-0152.2025.03.010
- VernacularTitle:重性抑郁障碍快感缺失的磁共振成像与神经生物学机制研究进展
- Author:
Peishan HUANG
1
;
Ke WANG
1
;
Xuelin ZHANG
1
;
Yi MIAO
1
;
Qiangli DONG
1
Author Information
1. 兰州大学第二医院(第二临床医学院)心理卫生科(兰州 730030)
- Publication Type:Journal Article
- Keywords:
Anhedonia;
Major depressive disorder;
Magnetic resonance imaging;
Brain structure;
Brain func-tion;
Brain network;
Reward network;
Neural mechanism
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(3):180-185
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder is a common mental disorder,one of the core symptoms of which is anhedonia,characterized by a reduced ability to respond to pleasurable stimuli.Brain images of patients with major depressive disorders with anhedonia show the following features:reduced volume or cortical thickness in brain regions such as the striatum and temporal lobe,changes in the microstructure of white matter tracts,abnormal neuronal activity in the frontal lobe,temporal lobe,and limbic system,and altered connectivity in the default mode network,reward network,and fronto-parietal network.Additionally,factors such as stress,gene expression,the glutamate system,and biological rhythms may also influence anhedonia.The neurobiological mechanisms of anhedonia are intricate,and are crucial for the diagnosis,treatment,and prognosis of depressive disorders.
