Efficacy of high-flux hemodialysis in the treatment of stage 5 chronic kidney disease and its effects on nutritional status
10.3760/cma.j.cn341190-20240923-01231
- VernacularTitle:高通量血液透析对慢性肾脏病5期患者的疗效及营养状况的影响
- Author:
Tian ZHANG
1
;
Zhongjie REN
1
;
Yueda LI
1
Author Information
1. 杭州市第三人民医院肾脏内科，杭州 310009
- Publication Type:Journal Article
- Keywords:
Renal dialysis;
Kidney failure, chronic;
Inflammation;
Blood urea nitrogen;
C-reactive protein;
Nutritional status
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(8):1181-1185
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy of high-flux hemodialysis in the treatment of stage 5 chronic kidney disease and its effects on nutritional status.Methods:A retrospective study was conducted on 64 patients with stage 5 chronic kidney disease who received treatment at Hangzhou Third People's Hospital from February 2023 to February 2024. These patients were divided into an observation group and a control group according to different blood purification methods, with 32 patients per group. The control group underwent conventional hemodialysis treatment, while the observation group underwent high-flux hemodialysis. Renal function, calcium and phosphorus metabolism, inflammatory factors, and nutritional indicators were compared between the two groups before and after treatment.Results:After treatment, the observation group showed significantly lower levels of serum creatinine [(238.18 ± 64.37) μmol/L] and blood urea nitrogen [(8.35 ± 1.43) μmol/L] compared with the control group [(343.12 ± 75.28) μmol/L, (10.97 ± 1.64) μmol/L, t = 5.99, 6.81, both P < 0.05]. The observation group had lower levels of calcium [(1.65 ± 0.19) mmol/L] and phosphorus [(1.54 ± 0.28) mmol/L] compared with the control group [(2.16 ± 0.23) mmol/L, (2.03 ± 0.36) mmol/L, t = 9.67, 6.08, both P < 0.05]. After treatment, the levels of C-reactive protein in the observation group [(9.72 ± 2.65) mg/L] were lower than those in the control group [(14.98 ± 3.76) mg/L, t = 6.47, P < 0.001]. However, there were no significant differences in hemoglobin, albumin, and prealbumin levels between the two groups ( t = -0.47, -0.16, -0.48, all P > 0.05). Conclusions:High-flux hemodialysis is effective in patients with stage 5 chronic kidney disease. It significantly alleviates the inflammatory state, but it has no notable effects on nutritional status. This approach merits consideration in clinical practice.
