Changes and significance of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and procalcitonin, C-reactive protein, and interleukin-6 levels in neonates with septicemia
10.3760/cma.j.cn341190-20240102-00002
- VernacularTitle:败血症新生儿NLR、MLR及PCT、CRP、IL-6的变化及意义
- Author:
Weichun LI
1
;
Shengdong WANG
1
;
Tingting XU
1
Author Information
1. 安徽医科大学附属滁州医院 滁州市第一人民医院检验科，滁州 239000
- Publication Type:Journal Article
- Keywords:
Sepsis;
Granulocytes;
Lymphocytes;
Monocytes;
C-reactive protein;
Interleukin-6;
Infant, newborn
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(7):1039-1043
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes and significance of neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and procalcitonin, C-reactive protein, and interleukin-6 levels in neonates with septicemia.Methods:This study used a retrospective analysis mehod. A total of 69 neonates with septicemia who received treatment at the Neonatal Ward, Children's Hospital, The First People's Hospital of Chu Zhou were included in the study group. A total of 43 neonates without septicemia were included in the control group. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and procalcitonin (PCT), C-reactive protein (CRP), and interleukin-6 (IL-6) levels were compared between the two groups. The changes in NLR, MLR, PCT, and CRP levels in neonates with septicemia were observed after treatment, compared with their pre-treatment levels. The receiver operating characteristic curve was used to analyze the value of laboratory indicators NLR, MLR, and PCT, CRP, and IL-6 levels in the diagnosis of septicemia in neonates.Results:The NLR, MLR, and PCT, CRP, and IL-6 levels in the study group were (4.79 ± 1.87), (0.49 ± 0.21), (8.41 ± 3.21) μg/L, (11.97 ± 4.23) mg/L, and (892.13 ± 361.43) ng/L, respectively. These values were significantly higher than those in the control group [(0.89 ± 0.23), (0.13 ± 0.06), (0.51 ± 0.26) μg/L, (2.16 ± 1.26) mg/L, (111.28 ± 51.69) ng/L, t = 10.11, 9.76, 23.06, 36.72, 15.74, all P < 0.05]. After treatment, NLR, MLR, and PCT and CRP levels in the study group were (3.04 ± 1.42), (0.29 ± 0.13), (1.26 ± 0.52) μg/L, and (3.28 ± 1.87) mg/L, respectively. These values were significantly lower than those measured before treatment in the same group [(4.79 ± 2.47), (0.49 ± 0.19), (8.41 ± 3.41) μg/L, (11.97 ± 5.26) mg/L, t = 6.50, 6.33, 33.05, 39.04, all P < 0.05]. The areas under the curve for NLR, MLR, and PCT, CRP, and IL-6 levels in diagnosing septicemia in neonates were 0.785, 0.765, 0.665, 0.763, and 0.753, respectively, with NLR showing the highest area under the curve. Conclusions:NLR and MLR are valuable for diagnosing and evaluating the prognosis of neonatal septicemia. Combined detection of PCT, CRP, and IL-6 levels can enhance the sensitivity and specificity of septicemia diagnosis.
