Cardiac Damage in Patients with Primary Aldosteronism and Different Degrees of Obstructive Sleep Apnea Syndrome
10.3870/j.issn.1672-0741.23.12.025
- VernacularTitle:原发性醛固酮增多症合并不同程度阻塞性睡眠呼吸暂停综合征患者的心脏损害
- Author:
Shaoying ZHENG
1
;
Mingshuang ZHOU
;
Xue LI
Author Information
1. 昆明医科大学附属心血管病医院/云南省阜外心血管病医院高血压病区,昆明 650221;昆明医科大学,昆明 650500
- Publication Type:Journal Article
- Keywords:
primary aldosteronism;
obstructive sleep apnea syndrome;
cardiac damage
- From:
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
2025;54(2):240-246
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of left ventricular hypertrophy in patients with primary aldosteron-ism(PA)accompanied by varying severity of obstructive sleep apnea(OSA),and to further identify potential factors contributing to ventricular hypertrophy in this population.Methods A retrospective analysis was performed on 308 patients with PA who received treatment at Kunming Medical University Affiliated Cardiovascular Hospital from January 2021 to June 2022.For com-parison,309 hospitalized patients diagnosed with essential hypertension(EH)during the same period were included as the control group.According to polysomnography findings,the patients were categorized into PA/EH with OSA group and PA/EH without OSA group.PA patients with OSA were further stratified into mild,moderate,and severe OSA subgroups based on the apnea-hypopnea index(AHI).Demographic characteristics,biochemical profiles,and echocardiographic parameters were compared across the groups.Results Compared to the EH groups with or without OSA,interventricular septal diastolic thickness(IVS-DT),left ventricular mass index(LVM),and left ventricular mass index(LVMI)was increased in PA with OSA group(all P＜0.05).The body mass index(BMI)was increased in both the PA with OSA group and EH with OSA group compared to their counterparts without OSA(all P＜0.05).Within the three subgroups of PA patients with OSA,left ventricular end-diastolic di-mension(LVEDD),IVSDT,left ventricular posterior wall diastolic thickness(LVPWDT),and LVM measurements were in-creased in severe OSA group compared to the mild OSA group(all P＜0.05).Conclusion Aldosterone is an independent risk factor from OSA for left ventricular hypertrophy;In PA patients with OSA,cardiac impairment is severer in the moderate and severe OSA subgroups compared to those without OSA,and the severity of cardiac impairment escalates as OSA severity increa-ses.These findings highlight the necessity of screening for OSA in PA patients to stratify cardiac impairment risk and enable early therapeutic intervention.
