Clinical analysis of 151 cases of infection with severe fever with thrombocytopenia syndrome virus
10.3760/cma.j.cn341190-20240723-00946
- VernacularTitle:新型布尼亚病毒感染151例临床分析
- Author:
Zheen ZHANG
1
;
Yan WANG
1
Author Information
1. 浙江省舟山医院感染科，舟山 316000
- Publication Type:Journal Article
- Keywords:
Bunyaviridae infections;
Nausea;
Fasciculation;
Thrombin time;
Alanine transaminase;
Creatine kinase
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(4):557-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics and features of patients infected with severe fever with thrombocytopenia syndrome virus (SFTSV).Methods:A retrospective analysis was conducted on the clinical data of 151 patients infected with SFTSV who were admitted to Zhoushan Hospital from January 2012 to January 2024. The patients were divided into two groups based on disease severity: 120 patients in the mild group and 31 patients in the severe group. Data collected included patient demographics (gender and age) and clinical features (such as fever, nausea and vomiting, muscle tremors, abdominal pain and diarrhea, hematemesis, and respiratory failure), as well as length of hospital stay. Laboratory tests included routine blood tests, coagulation indicators, liver and kidney function, and cardiac enzyme levels.Results:There were no statistically significant differences between the mild and severe groups in terms of gender, age, abdominal pain and diarrhea, hematemesis, and respiratory failure symptoms (all P > 0.05). However, the incidences of nausea and vomiting [54.84% (17/31)] and muscle tremors [51.61% (16/31)] were higher in the severe group compared with the mild group [30.83% (37/120) and 21.43% (34/120), χ2 = 6.18, 6.03, both P < 0.05]. The length of hospital stay was longer in the severe group [(16.87 ± 4.76) days] than in the mild group [(9.79 ± 2.54) days, t = 11.27, P < 0.05]. The activated partial thromboplastin time in the severe group [(43.42 ± 34.21) seconds] was longer than that in the mild group [(34.21 ± 5.65) seconds, t = 7.42, P < 0.05]. Additionally, the levels of aspartate aminotransferase [(453.19 ± 43.21) U/L] and alanine aminotransferase [(167.32 ± 35.49) U/L] in the severe group were higher than those in the mild group [(368.81 ± 32.25) U/L, (120.93 ± 28.31) U/L, t = 12.06, 7.70, both P < 0.05]. Furthermore, creatine kinase [(418.34 ± 37.17) U/L] and creatine kinase-MB [(32.51 ± 5.57) U/L] levels were also higher in the severe group compared with the mild group [(345.19 ± 32.06) U/L, (26.38 ± 4.61) U/L, t = 10.95, 6.31, both P < 0.05]. Conclusions:The clinical features of patients with severe SFTSV infection are characterized by a high incidence of nausea and muscle tremors, as well as coagulation abnormality, myocardial injury, and liver function abnormality, all of which are important for clinical consideration.
