Research progress on the interaction between hyperuricemia and lipid accumulation
10.3760/cma.j.cn115822-20240622-00107
- VernacularTitle:高尿酸血症与脂肪堆积相互作用的研究进展
- Author:
Yuying WANG
1
;
Fei YE
1
;
Xuechen LI
1
Author Information
1. 中国医学科学院 北京协和医学院药物研究所，北京 100050
- Publication Type:Journal Article
- Keywords:
Hyperuricemia;
Lipid accumulation;
Insulin resistance;
Oxidative stress
- From:
Chinese Journal of Clinical Nutrition
2024;32(6):378-384
- CountryChina
- Language:Chinese
-
Abstract:
Along with the evolution in lifestyle and dietary structure and improvement in socioeconomic level, there has been an increase in the prevalence rate of hyperuricemia (HUA) and obesity. HUA is closely related with lipid accumulation and both are independent risk factors for one another. HUA induces lipid accumulation through oxidative stress and glucose metabolism dysfunction. The mechanisms involved in HUA-induced lipid accumulation include increasing pro-inflammatory factors, mitochondrial oxidative stress, inducing fructose metabolism and activating ChREBP. The imbalance between uric acid production and excretion is the root cause of HUA. Lipid accumulation impacts both the production and the excretion of uric acid, thus elevating serum uric acid level and eliciting HUA. The mechanisms by which lipid accumulation induces HUA include reducing glomerular filtration, decreasing uric acid reabsorption, increasing enzyme activity related to uric acid production and increasing concentration of substrates for uric acid synthesis. Here, we reviewed the mutual promoting mechanisms between HUA and lipid accumulation, which may provide atheoretical support for rational drug use in HUA combined with obesity or fatty liver disease and inform relative innovative drug development.
