The role of biomarkers in the diagnosis and prediction of disease progression of IgA nephropathy
10.3969/j.issn.1006-5725.2025.09.001
- VernacularTitle:生物标志物在IgA肾病诊断及预测疾病进展中的作用
- Author:
Lu ZHAO
1
;
Huiwen ZHI
1
;
Yafeng LI
1
Author Information
1. 山西医科大学附属山西省人民医院肾内科、山西医科大学第五临床医学院(山西 太原 030012)
- Publication Type:Journal Article
- Keywords:
IgA nephropathy;
biomarkers;
protein;
nucleic acid;
diagnosis;
progression
- From:
The Journal of Practical Medicine
2025;41(9):1267-1272
- CountryChina
- Language:Chinese
-
Abstract:
IgA nephropathy(IgAN)is one of the most prevalent forms of primary glomerulonephritis globally and a leading cause of end-stage renal disease(ESRD).The exact pathogenesis and progression mechanisms of IgAN remain unclear.Its clinical manifestations are diverse,with varying degrees of kidney involvement reflected in both clinical presentations and pathological changes.Consequently,responses to treatment and prognoses differ significantly among patients.Currently,renal needle biopsy serves as the gold standard for diagnosing IgAN;how-ever,this invasive procedure is often not well-accepted by patients,limiting its widespread clinical application and complicating disease diagnosis.Therefore,non-invasive biomarkers are crucial for assisting in the diagnosis of IgAN and evaluating the risk of disease progression.Below,we will focus on various serum and urinary biomarkers associated with IgAN at both protein and nucleic acid levels.
