Diagnostic predictive value of preoperative hematological inflammatory markers in differentiating malignant and benign primary retroperitoneal tumors
10.3760/cma.j.cn115807-20240719-00244
- VernacularTitle:术前血液学炎症指标在原发性腹膜后肿瘤良恶性鉴别中的价值
- Author:
Wenyang PANG
1
;
Wenjing CHEN
;
Jinji JIN
;
Wenyi WU
;
Pengfei WANG
;
Guanbao ZHU
;
Xiaolei CHEN
;
Yiqi CAI
Author Information
1. 台州市立医院肿瘤外科，台州 318000
- Publication Type:Journal Article
- Keywords:
Retroperitoneal tumors;
Lymphocyte;
Platelet
- From:
Chinese Journal of Endocrine Surgery
2024;18(6):865-869
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the predictive value of hematological inflammatory markers such as preoperative monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and several tumor-related factors in differentiating malignant and benign primary retroperitoneal tumors (PRTs) .Methods:This study retrospectively collected the data of 159 pathologic confirmed PRTs patients who underwent surgery in the First Affiliated Hospital of Wenzhou Medical University and Taizhou Municipal Hospital between Dec. 2009 and Aug. 2020. Univariate analysis of clinic data was performed to identify the differences between the benign and malignant PRTs. Logistic regression analysis was used to determine the independent predictive parameters for malignant PRTs.Results:Among the 159 patients with PRTs, 80 were malignant, 68 were benign, and 11 were borderline. Contrast with benign and borderline tumor, univariate analysis demonstrated that tumor size, preoperative neutrophil count, platelet count, albumin level, MLR, NLR and PLR exhibited significant differences in malignant tumor (all P<0.05). PLR (HR=1.025, P=0.020) and tumor size (HR=1.085, P=0.006) were independent risk factors for predicting malignant PRTs in the multivariate logistic analyses. According to the ROC curve, the optimal cutoff value of tumor size and PLR for predicting malignant PRTs were 194.85 (sensitivity 38.7%, specificity 93.5%), 8.75 cm (sensitivity 69.3%, specificity 72.7%), respectively. Conclusions:Preoperative PLR is useful in differentiating malignant and benign PRTs and it is an independent risk parameter for malignant PRTs. Preoperative PLR could be considered as a new significant predictor for malignant PRTs.
