Relationship between thyroid function status and muscle-related indicators, as well as chemokines and 25 (OH) D in elderly patients with type 2 diabetes mellitus
10.3760/cma.j.cn115807-20240626-00218
- VernacularTitle:甲状腺功能状态与老年T2DM患者肌肉相关指标及趋化素、25（OH）D的相互关系
- Author:
Huadong ZHENG
1
;
Li XU
;
Ming LI
;
Bin YUE
Author Information
1. 西安交通大学第二附属医院老年病科，西安 710004
- Publication Type:Journal Article
- Keywords:
Thyroid function;
Elderly;
Type 2 diabetes;
Bone metabolism;
Chemokines;
25-hydroxyvitamin D;
Interaction;
Osteoporosis
- From:
Chinese Journal of Endocrine Surgery
2024;18(6):824-829
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between thyroid function status and related indicators of muscle and bone metabolism, as well as serum levels of chemerin and 25-hydroxyvitamin D [25 (OH) D] in elderly patients with type 2 diabetes mellitus (T2DM) .Methods:A total of 158 elderly T2DM patients admitted to Department of Gerontology, Second Affiliated Hospital of Xi’an Jiaotong University from Mar. 2022 to Mar. 2024 were selected as the study subjects. According to whether they had osteoporosis (OP), they were included in the concurrent group (61 cases) and the non-concurrent group (97 cases). The baseline data, muscle (grip strength, muscle content), bone metabolism [osteocalcin, bone-specific alkaline phosphatase (BAP) ] related indicators, and serum Chemerin and 25 (OH) D levels were compared between the two groups. The partial correlation coefficient was used to analyze the partial correlation between the above indicators and the concurrent OP in elderly patients with T2DM. The levels of muscle, bone metabolism-related indicators and serum indicators were compared among patients with different thyroid function status, and the interaction coefficient γ was used to analyze the interactive effects of abnormal thyroid function status on muscle, bone metabolism-related indicators and serum indicators.Results:There were significant differences in the duration of T2DM, thyroid function status, glycosylated hemoglobin (HbA1c), muscle content, osteocalcin, 25 (OH) D, BAP, and Chemerin levels between the two groups ( t/ χ 2=4.564, 7.900, 8.184, -2.028, -7.708, -6.927, 3.167, 14.298, P<0.05). Partial correlation analysis showed that thyroid function status (hyperthyroidism, hypothyroidism), muscle content, osteocalcin, BAP, Chemerin, and 25 (OH) D were significantly associated with the occurrence of OP in elderly T2DM patients (partial correlation coefficients = 0.814, 0.827, -0.675, -0.759, 0.732, 0.848, -0.702, P<0.05). The levels of osteocalcin, BAP, and Chemerin were higher in elderly T2DM patients with hyperthyroidism than in those with hypothyroidism and normal thyroid function, and those with hypothyroidism were higher than those with normal thyroid function, showing significant differences ( F=118.845, 7.444, 54.253, P<0.05). Interaction analysis revealed that both hypothyroidism and hyperthyroidism had multiplicative and additive interactions with osteocalcin and Chemerin, and the synergistic effect could be several times higher than the sum of the effects of the two, increasing the risk of OP ( RERI=8.216, 15.472, SI=1.414, 2.053, P<0.001) . Conclusions:The thyroid function status is closely related to the muscle and bone metabolism-related indicators, as well as serum levels of Chemerin and 25 (OH) D in elderly patients with T2DM complicated by OP. The concurrent exposure of thyroid dysfunction to osteocalcin and Chemerin can synergistically increase the risk of elderly T2DM complicated by OP. The combined application can serve as a novel auxiliary scheme for clinical prediction of OP and has certain guiding significance for clinical prevention and treatment.
