Incidence and influencing factors of ocular surface disease among power grid construction workers in plateau: a real-world study
10.3760/cma.j.cn115989-20230323-00098
- VernacularTitle:基于真实世界数据分析高原作业电网施工人员眼表疾病发病率及影响因素
- Author:
Xinyu YANG
1
;
Yunjing ZHANG
;
Huziwei ZHOU
;
Quanquan GONG
;
Xinyu WANG
;
Xiaoyu ZHANG
;
Zhixia LI
;
Shiming LI
;
Shengfeng WANG
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系 重大疾病流行病学教育部重点实验室，北京 100191
- Publication Type:Journal Article
- Keywords:
Conjunctivitis;
Keratitis;
Incidence;
Cohort studies;
Associated factors;
Ocular surface diseases;
High-altitude workers
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(5):443-451
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the incidence and risk factors of ocular surface disease among power grid construction workers in plateau.Methods:A total of 11 132 construction personnel from the Ngari prefecture-central Tibet power grid interconnection project were included from 2019 to 2020.Baseline characteristics including age, gender, body mass index, developmental and nutritional status, relevant clinical indicators, etc.and follow-up data regarding incidence of ocular surface diseases were obtained from the medical records of Ali interconnection project staff medical station.The altitude of workplace and residence of the study population were obtained from the website (https: //zh-cn.topographic-map.com/legal/).The mean age of the subjects was (36.17±10.48) years, of which 95.33%(10, 612 subjects) were male.The median follow-up time was 1.53 years.The altitude of the residence and workplace were (1 954.77±940.64) and (4 535.09±232.71) meters, respectively.The incidence of ocular surface diseases in groups with different characteristics was calculated.Differential variables for the incidence of ocular surface diseases were screened by univariate Cox proportional hazards regression model.Influencing factors of ocular surface diseases multivariate were explored by Cox proportional hazards model.This study was approved by the Ethics Committee of Peking University Health Science Center (No.IRB00001052-21066).Results:During the follow-up period, the incidence of ocular surface disease was 9.27% (1 032 cases), and the incidence of conjunctivitis and keratitis was 6.58% (733 cases) and 1.80% (200 cases), respectively.Multivariate Cox proportional hazards regression analysis showed that for every 1 000 meters increase in altitude of residence, the risk of ocular surface disease decreased by 15% ( HR[95% CI]: 0.85[0.80~0.91], P<0.001).For every 100 meters increase in altitude of workplace, the risk of ocular surface disease increased by 5% ( HR[95% CI]: 1.04[1.01~1.07], P=0.006).Decreased blood oxygen saturation ( HR[95% CI]: 1.09[1.02~1.16], P=0.007), hearing pulmonary dry rales (hazard ratio ( HR)[95% CI]: 1.53[1.12~2.09], P=0.007) and heart murmurs ( HR[95% CI]: 4.44[1.43~13.83], P=0.010) were associated with ocular surface disease. Conclusions:The incidence of ocular surface disease in personnel engaged in electric grid construction at high altitudes should not be ignored.High working altitude, low residence altitude, pulmonary dry rales, heart murmurs and low blood oxygen saturation are factors associated with the incidence of ocular surface disease.
