Research progress in animal models of allergic conjunctivitis
10.3760/cma.j.cn115989-20220930-00464
- VernacularTitle:变应性结膜炎动物造模研究进展
- Author:
Jiaxun ZHANG
1
;
Yuxi HE
;
Yan ZHANG
Author Information
1. 吉林大学白求恩第二临床医学院，长春 130041
- Publication Type:Journal Article
- Keywords:
Allergic conjunctivitis;
Modeling method;
Animal model;
Sensitized cells
- From:
Chinese Journal of Experimental Ophthalmology
2025;43(4):378-384
- CountryChina
- Language:Chinese
-
Abstract:
Allergic conjunctivitis has a high incidence rate, which is difficult to cure after repeated attacks, and seriously affects people's quality of life.Animal models are the main tools and means for the study of allergic conjunctivitis diseases, and animal modeling is an important step in the study of allergic conjunctivitis diseases.Because the study of allergic conjunctivitis is relatively late than that of other allergic diseases, the animal model of allergic conjunctivitis mainly refers to the animal model building methods of allergic asthma, rhinitis and other allergic diseases, or makes improvements on them, resulting in a variety of animal model building methods, poor reference of animal model building methods, and low survival rate and success rate of animal model building.This paper analyzes the pathogenic mechanism of allergic conjunctivitis and the purpose of animal modeling, searches and analyzes the modeling process of allergic conjunctivitis in Pubmed in the past 10 years, sorted and analyzed the modeling methods according to the sensitization mechanism, and summarized four modeling process models, which provided a reference for the selection of animal strains, sensitization dose and sensitization process in the modeling of allergic conjunctivitis.
