Efficacy of low-dose morphine epidural injection in the management of postpartum analgesia
10.3760/cma.j.cn341190-20240710-00884
- VernacularTitle:小剂量吗啡硬膜外腔注射用于产后镇痛的效果观察
- Author:
Shiqian ZHANG
1
;
Xia LI
1
Author Information
1. 东阳市妇幼保健院产科，东阳 322100
- Publication Type:Journal Article
- Keywords:
Analgesia,obstetrical;
Morphine;
Dose-response relationship,drug;
Analgesia,epidural;
Prolactin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(4):567-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of low-dose morphine epidural injection on postpartum analgesia.Methods:In this prospective study, 200 women who underwent painless delivery at Dongyang Maternal and Child Health Hospital from January to December 2023 were selected as research subjects. They were randomly divided into a control group ( n = 100) and an observation group ( n = 100) using a random number table method. The control group received an epidural injection of 0.9% sodium chloride solution postpartum, while the observation group received an epidural injection of 2 mg morphine postpartum. Analgesic effects, the degree of uterine contractions, breastfeeding status, and the incidence of adverse reactions were compared between the two groups. Results:The onset time of analgesia in the observation group was significantly shorter than that in the control group [(2.24 ± 0.64) minutes vs. (2.65 ± 0.71) minutes, t = 4.28, P < 0.05]. The duration of analgesia and pain recovery time were (327.19 ± 74.27) minutes and (56.29 ± 17.31) minutes, respectively, which were longer than those in the control group [(302.18 ± 62.31) minutes, (48.22 ± 12.06) minutes, t = -2.58, -3.82, both P < 0.05]. Within 24 hours postpartum, the intensity of uterine contraction pain gradually increased in both groups; however, the observation group consistently reported lower pain levels than the control group ( t = 16.14, 13.13, 12.85, 12.37, 11.15, all P < 0.05). The number of breastfeeding sessions in the observation group was significantly higher than that in the control group [(15.32 ± 3.52) vs. (10.85 ± 2.34), t = -10.57, P < 0.05]. On postpartum day 1, the prolactin levels in both groups were higher than pre-delivery levels, with the observation group showing higher levels [(338.65 ± 75.07) μg/L] compared with the control group [(271.37 ± 52.71) μg/L, t = -7.33, P < 0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group [10.00% (10/100) vs. 6.00% (6/100), χ2 = 1.08, P > 0.05). Conclusions:The use of low-dose morphine administered via epidural injection provides effective analgesia for postpartum uterine contraction pain, improves breastfeeding, and does not increase the incidence of adverse reactions.
