Relationship between plasma levels of protein C, protein S, antithrombin III, and D-dimer in patients with preeclampsia and fetal growth restriction
10.3760/cma.j.cn341190-20240629-00835
- VernacularTitle:子痫前期患者血浆蛋白C、蛋白S、抗凝血酶Ⅲ及D-二聚体水平与胎儿生长受限的关系
- Author:
Xiaohong LI
1
;
Shixian WANG
1
Author Information
1. 濮阳市妇幼保健院检验科，濮阳 457000
- Publication Type:Journal Article
- Keywords:
Pre-eclampsia;
Fetal growth retardation;
Protein C;
Protein S;
Antithrombin Ⅲ
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(4):508-512
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between plasma levels of protein C(PC), protein S (PS), antithrombin Ⅲ (AT-Ⅲ), and D-dimer (D-D) in patients with preeclampsia and fetal growth restriction (FGR).Methods:A retrospective analysis was conducted to identify 40 patients with preeclampsia complicated by FGR who underwent examination and delivery at the Department of Obstetrics, Puyang Maternal and Child Health Hospital, between January 2021 and January 2023. These patients constituted the study group. An additional 40 patients with preeclampsia that did not develop FGR were selected as the control group. A case-control study design was used to compare general information and levels of PC, PS, AT-Ⅲ, and D-D between the two groups. The areas under the receiver operating characteristic curve for PC, PS, AT-Ⅲ, and D-D were calculated to assess their diagnostic value for FGR.Results:In the study group, the plasma levels of PC [(91.94 ± 10.34)%], PS [(68.79 ± 12.27)%], and AT-Ⅲ [(80.66 ± 9.13)%] were significantly lower than those in the control group [(107.73 ± 13.68)%, (79.62 ± 13.05)%, (92.31 ± 10.54)%, t = 5.82, 3.82, 5.28, all P < 0.05]. Additionally, the level of in the study group [(0.94 ± 0.26) ng/L] was higher than that in the control group [(0.52 ± 0.28) ng/L, t = 6.95, P < 0.05]. Logistic multivariate analysis showed that reduced level of PC ( OR = 1.142), reduced level of PS ( OR = 1.073), reduced level of AT-Ⅲ ( OR = 1.138), and elevated D-D levels ( OR = 1.946) were all risk factors for FGR in patients with preeclampsia (all P < 0.05). The receiver operating characteristic curve analysis for diagnosing FGR in preeclampsia patients indicated area under the curve values of 0.840 for PC, 0.719 for PS, 0.772 for AT-Ⅲ, and 0.819 for D-D. Conclusions:In patients with preeclampsia complicated by FGR, the plasma levels of PC, PS, and AT-Ⅲ are all decreased, while D-D levels are elevated, indicating a hypercoagulable state. Therefore, measuring the plasma levels of PC, PS, AT-Ⅲ, and D-D can assist in diagnosing preeclampsia complicated by FGR.
