Analysis of vaginal microecological changes in patients with vaginal infectious diseases and their correlation with human papillomavirus infection
10.3760/cma.j.cn341190-20240621-00788
- VernacularTitle:阴道感染疾病患者阴道微生态改变分析及其与HPV感染的相关性研究
- Author:
Hua ZHANG
1
;
Yewei DING
;
Lei LI
;
Jingbo CHEN
Author Information
1. 永康市妇幼保健院检验科，永康 321300
- Publication Type:Journal Article
- Keywords:
Papillomavirus infections;
Vaginosis, bacterial;
Trichomonas vaginitis;
Hydrogen peroxide;
Acid-base equilibrium
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(4):503-507
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze vaginal microecological changes in patients with vaginal infectious diseases and their correlation with human papillomavirus (HPV) infection.Methods:A case-control study was conducted involving 416 patients who visited the Gynecology Outpatient Department and the Cervical Disease Clinic at Yongkang Maternity and Child Care Hospital between December 2022 and December 2023. All patients underwent testing for vaginal microecology and HPV to evaluate the prevalence of vaginal infectious diseases and HPV infection. Vaginal microecological indicators were compared between patients with vaginal infections and those without identifiable pathogenic bacterial dysbiosis. The indicators included microbial density, lactobacilli levels, pH, hydrogen peroxide levels, abnormal leukocyte esterase, and the grading of vaginal lactobacilli. Additionally, the HPV infection status was compared among patients with different vaginal microecological environments, and the correlation between vaginal infections and HPV infections was analyzed.Results:In a study involving 416 participants, 216 were diagnosed with vaginal infections, with an incidence rate of 51.92% (216/416). Among these cases, 118 were classified as a single infection, accounting for 54.63% (118/216), while 98 were identified as mixed infections, accounting for 45.37% (98/216). The rate of HPV infection among the 216 patients with vaginal infectious diseases was 37.04% (80/216). This rate was significantly higher than the 15.31% (30/196) observed in patients without identifiable pathogenic bacterial dysbiosis ( χ2 = 24.79, P < 0.001). Patients with vaginal infectious diseases also displayed elevated rates of abnormal lactobacilli levels, abnormal pH, abnormal leukocyte esterase, and abnormal lactobacilli grading, with rates of 59.26%, 86.57%, 72.69%, and 57.41%, respectively. In comparison, patients without identifiable pathogenic dysbiosis had rates of 31.12%, 18.88%, 51.53%, and 34.18%, respectively. All differences were statistically significant ( χ2 = 32.76, 86.83, 19.64, 22.28, all P < 0.001). Additionally, significant differences in HPV infection rates were observed among patients who tested positive for bacterial vaginosis, vulvovaginal candidiasis, and trichomoniasis when compared to those who tested negative ( χ2 = 12.46, 4.04, 6.14, P < 0.001, 0.044, 0.013). Both bacterial vaginosis and vulvovaginal candidiasis were recognized as high-risk factors for HPV infection ( OR = 4.039, 2.902, both P < 0.05). Conclusions:Vaginal infectious diseases are significantly linked to HPV infection, particularly bacterial vaginosis and vulvovaginal candidiasis. Analyzing the characteristics of the vaginal microbiota can enhance the clinical management of HPV infection.
