Research progress and mechanism of the effect of per- and polyfluoroalkyl substances exposure on male semen quality
10.3760/cma.j.cn101441-20250327-00154
- VernacularTitle:全氟和多氟烷基物质对男性精液质量的影响及机制研究进展
- Author:
Weifeng TANG
1
;
Tao LI
;
Litao ZENG
;
Qianlong ZHANG
;
Xiangfeng CHEN
Author Information
1. 上海交通大学医学院附属新华医院环境与儿童健康教育部 上海市重点实验室，上海 200092
- Publication Type:Journal Article
- Keywords:
Persistent organic pollutant;
Per- and polyfluoroalkyl substances;
Semen quality;
Epidemiological studies;
Mechanism studies
- From:
Chinese Journal of Reproduction and Contraception
2025;45(7):672-678
- CountryChina
- Language:Chinese
-
Abstract:
Per- and polyfluoroalkyl substances (PFAS) are a class of persistent organic pollutants widely present in the environment. They can enter the human body through multiple pathways such as air, water, and diet, and tend to bioaccumulate. In recent years, increasing attention has been paid to the potential impacts of PFAS exposure on male reproductive health. This review systematically summarizes the characteristics of PFAS exposure in men and its effects on semen quality. Epidemiological evidence indicates that PFAS exposure is significantly associated with reduced sperm concentration, motility, and normal morphologyrate. Mechanistic studies suggest that PFAS may induce male reproductive toxicity through various pathways, including germ cell cytotoxicity, dysfunction of Sertoli cells, endocrine disruption, oxidative stress, and epigenetic regulation. This review aims to integrate current evidence to support the assessment of male reproductive risks associated with PFAS exposure and to inform the development of preventive strategies.
