Regulatory role of DNA demethylation mediated by TET protein in mammalian embryonic development and pregnancy outcome
10.3760/cma.j.cn101441-20250111-00014
- VernacularTitle:TET蛋白介导的DNA去甲基化在哺乳动物胚胎发育与妊娠结局中的调控作用
- Author:
Tianxi YAN
1
;
Xiaoli ZHAO
1
;
Linling WU
1
;
Shiman CHENG
1
;
Yu WU
1
;
Haijiao ZHANG
1
;
Yaxuan SUN
1
;
Chenxi LI
1
;
Jia JIA
1
Author Information
1. 天津中医药大学第一附属医院生殖医学科 国家中医针灸临床医学研究中心，天津 300381
- Publication Type:Journal Article
- Keywords:
Embryonic development;
Pregnancy outcome;
Epigenetic modification;
TET protein;
DNA demethylation
- From:
Chinese Journal of Reproduction and Contraception
2025;45(6):644-648
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is an important epigenetic modification in mammals, playing a crucial role in various physiological processes, including cell differentiation and the gene expression regulation. The ten-eleven translocation (TET) protein family of DNA demethylases is integral to the regulation of DNA methylation, as it catalyzes the oxidation of 5-methylcytosine to form 5-hydroxymethylcytosine. During early embryonic development, the genome undergoes extensive DNA demethylation, and any aberration in this reprogramming process can result in abnormal embryonic development and physiological defects in offspring. The TET proteins, due to their unique dynamics and multifaceted roles, facilitate DNA demethylation and are involved in development and maturation of germ cells, the establishment of pluripotency, cell lineage differentiation, and transcriptional processes throughout mammalian embryogenesis. Furthermore, these proteins are closely associated with the maintenance of pregnancy and susceptibility of progeny to disease. Factors such as genetic mutations, maternal health conditions, and exposure to adverse environmental influences can impact TET protein activity, resulting in abnormal patterns of DNA demethylation. A comprehensive investigation of the related mechanisms of TET proteins is essential for enhancing our understanding of epigenetic regulation during early life, diagnosing and treating related diseases such as early fetal development retardation, and informing strategies for the prevention and management of pregnancy.This article reviews the regulatory role of DNA demethylation mediated by TET protein in mammalian embryonic development and pregnancy outcomes.
