A study on rehabilitation exercise delaying the progression of chronic obstructive pulmonary disease by regulating NADPH oxidase in lung
10.3969/j.issn.1001-1242.2025.04.003
- VernacularTitle:康复运动通过调节大鼠肺脏NADPH氧化酶延缓慢性阻塞性肺疾病进程的研究
- Author:
Weiliang SUN
1
;
Jing GUO
;
Yuting ZHANG
Author Information
1. 中日友好医院临床医学研究所,北京市,100029
- Publication Type:Journal Article
- Keywords:
chromc obstructive pulmonary disease;
NADPH oxidase;
hypoxia inducible factor;
matrix metalloproteinase
- From:
Chinese Journal of Rehabilitation Medicine
2025;40(4):495-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of NADPH oxidase(Nox)in chronic obstructive pulmonary disease(COPD).Method:The rats were randomly divided into control group,COPD group,COPD medium exercise group and COPD intensive exercise group,with 10 rats in each group.The expression of NADPH oxidase,hypoxia induc-ible factor-1 alpha(HIF1α),inflammatory factors tumor necrosis——factor alpha(TNFα),interleukin-6(IL-6),matrix metalloproteinase 2(MMP-2)and matrix metalloproteinase 9(MMP-9)were detected by immunohistochemistry.Result:Compared with the control group,the expression of NADPH oxidase subtypes Nox1,Nox2,Nox5,HIF1α,TNFα,IL-6,MMP-2 and MMP-9 in COPD group increased significantly.Medium exercise reduced the expression of Nox2,Nox5,HIF1α and MMP-9 in COPD animal model,while intensive exercise reduced the expression of Nox1,Nox2,Nox5,HIF1α,TNFα,IL-6 and MMP-9.Conclusion:Rehabilitation exercise down regulated the expression of NADPH oxidases in lung,reduced the expression of downstream inflammatory factors and matrix metalloproteinase.The protective function of rehabili-tation exercise might achieve by inhibiting the expression of hypoxia inducible factor.
