Risk factors of poor prognosis in older adult patients with acute respiratory failure induced by septic shock
10.3760/cma.j.cn341190-20240611-00721
- VernacularTitle:老年脓毒症休克致急性呼吸衰竭患者预后不良危险因素分析
- Author:
Fen WU
1
;
Jie YANG
1
;
Rongmei ZHAO
1
;
Liangmei FAN
1
;
Yuqun XIA
1
Author Information
1. 丽水市中心医院感染科,丽水 323000
- Publication Type:Journal Article
- Keywords:
Shock, septic;
Respiratory insufficiency;
Serum albumin;
Calcium;
Prognosis;
Root cause analysis;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(2):210-213
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the risk factors of poor prognosis in older adult patients with acute respiratory failure (ARF) induced by septic shock.Methods:A retrospective analysis was performed on the clinical data of 146 patients with ARF induced by septic shock who received treatment at Lishui Central Hospital between January 2020 and December 2022. According to prognosis, these patients were divided into a good prognosis group and a poor prognosis group. The factors that affect the prognosis were analyzed by regression analysis.Results:Among the 146 patients, there were 102 cases (69.86%) with a good prognosis and 44 cases (30.14%) with a poor prognosis. The incidence of multidrug-resistant bacterial infections and the Murray lung injury score in the poor prognosis group were 54.54% (24/44) and (2.11 ± 1.02), respectively, both of which were significantly higher than those in the good prognosis group [23.53% (24/102), (3.29 ± 0.12), χ2 = 13.40, t = 7.63, both P < 0.001]. In the poor prognosis group, the usage rate of beta-blockers was 34.09% (15/44), while oxygenation index and serum levels of albumin and Ca 2+ were (211.32 ± 44.56) mmHg (1 mmHg = 0.133 kPa), (27.02 ± 5.21) g/L, and (2.19 ± 0.25) mmol/L, respectively. These values were significantly lower than those in the poor prognosis group [63.73% (65/102), (257.46 ± 49.65) mmHg, (30.57 ± 5.45) g/L, (2.52 ± 0.31) mmol/L, χ2 = 10.89, t = 5.54, 3.65, 6.23, all P < 0.001]. An increased Murray lung injury score, the presence of multidrug-resistant bacterial infections, and decreased serum levels of Ca 2+ and albumin were independent risk factors for poor prognosis in patients with ARF induced by septic shock ( OR = 1.958, 2.100, 2.147, 2.098, all P < 0.05). Conversely, the use of beta-blockers was identified as a protective factor for prognosis ( OR = 0.480, P = 0.025). Conclusions:Multidrug-resistant bacterial infections, low oxygenation index, and decreased serum levels of Ca 2+ and albumin are independent risk factors for poor prognosis in patients with ARF induced by septic shock. Conversely, the use of beta-blockers serves as a protective factor for prognosis.
