Research advances on the impact of endometrial epithelial cell senescence on endometrial receptivity
10.3760/cma.j.cn101441-20250403-00167
- VernacularTitle:子宫内膜上皮细胞衰老对子宫内膜容受性影响的研究进展
- Author:
Qin HU
1
;
Hui LI
1
;
Tianli YANG
1
;
Yanping LI
1
;
Jing ZHAO
1
Author Information
1. 中南大学湘雅医院生殖医学中心，长沙 410008
- Publication Type:Journal Article
- Keywords:
Endometrium;
Senescence;
Endometrial receptivity;
Senescence-associated secretory phenotype
- From:
Chinese Journal of Reproduction and Contraception
2025;45(11):1119-1123
- CountryChina
- Language:Chinese
-
Abstract:
With the global trend of delaying childbearing, the decline in female fertility has emerged as a critical public health concern. While previous research predominantly focused on ovarian failure, recent studies have revealed that endometrial aging and impaired endometrial receptivity are closely associated, serving as significant contributors to reproductive failures such as embryo implantation failure and recurrent miscarriage. This review aims to explore the impact of age-related and pathological endometrial epithelial cell senescence on the impairment of endometrial receptivity, with a focus on key factors including the senescence-associated secretory phenotype, oxidative stress, cellular-level alterations (e.g., abnormalities in cilia proportion and function), and the endometrial microenvironment. By elucidating the molecular mechanisms and signaling pathways underlying endometrial epithelial senescence, this review seeks to advance the development of effective interventions, offering novel therapeutic strategies to enhance endometrial receptivity and improve fertility outcomes among advanced-age women.
