Diagnostic value of heparin-binding protein, pro-adrenomedullin, and N-terminal pro-brain natriuretic peptide in assessing the severity of pulmonary infection in patients with chronic heart failure
10.3760/cma.j.cn341190-20240603-00676
- VernacularTitle:血清HBP、pro-ADM及NT-proBNP对CHF患者肺部感染严重程度的诊断价值
- Author:
Xiangfeng YAN
1
;
Guolong LIU
Author Information
1. 陕西省康复医院重症医学科，西安 710065
- Publication Type:Journal Article
- Keywords:
Heart failure;
Respiratory tract infections;
Pneumonia;
Adrenomedullin;
Natriuretic peptide, brain;
Forecasting;
Diagnosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(2):177-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the diagnostic value of heparin-binding protein (HBP), pro-adrenomedullin (pro-ADM), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in assessing the severity of pulmonary infection in patients with chronic heart failure (CHF).Methods:A cross-sectional study was conducted on 100 patients with CHF and pulmonary infection who were admitted to Shaanxi Rehabilitation Hospital between April 2021 and April 2023. According to clinical pulmonary infection score, the patients were classified into mild ( n = 43), moderate ( n = 31), and severe ( n = 26) groups. Additionally, 50 CHF patients without pulmonary infection, who were admitted during the same period, were included in the control group. General demographic data, as well as levels of HBP, pro-ADM, and NT-proBNP were compared among the groups. Logistic regression analysis was performed to identify the factors associated with the occurrence of pulmonary infection in CHF patients, while Pearson correlation analysis was used to assess the correlations among these indicators. Results:The levels of HBP, pro-ADM, and NT-proBNP in the severe group were (36.59 ± 4.15) μg/L, (3.69 ± 0.85) nmoL/L, and (9.63 ± 1.61) μg/L, respectively. In the moderate group, the levels were (33.09 ± 3.67) μg/L, (3.24 ± 0.58) nmoL/L, and (8.15 ± 1.42) μg/L, respectively. In the mild group, the levels were (29.12 ± 3.38) μg/L, (2.65 ± 0.37) nmoL/L, and (6.67 ± 0.68) μg/L, respectively. Significant differences were found in the levels of HBP, pro-ADM, and NT-proBNP among the three groups ( F = 34.41, 26.27, 48.53, all P < 0.05). The levels of HBP, pro-ADM, and NT-proBNP in patients with CHF and pulmonary infection were (32.29 ± 3.25) μg/L, (3.09 ± 0.41) nmoL/L, and (7.89 ± 0.92) μg/L, respectively, which were significantly higher than those in healthy controls [(26.54 ± 2.47) μg/L, (2.32 ± 0.32) nmoL/L, (5.65 ± 0.82) μg/L, t = 12.05, 12.61, 18.17, all P < 0.05]. Logistic regression analysis showed that a history of smoking, New York Heart Association (NYHA) functional classification, the presence of diabetes, as well as levels of HBP, pro-ADM, and NT-proBNP, were all factors influencing the occurrence of pulmonary infection in patients with CHF (all P < 0.05). Pearson analysis revealed that the levels of HBP, pro-ADM, and NT-proBNP in patients with CHF were significantly positively correlated with clinical pulmonary infection score ( r = 0.581, 0.540, 0.653, all P < 0.05). Conclusions:Serum levels of HBP, pro-ADM, and NT-proBNP have good predictive value for the severity of pulmonary infection in patients with CHF.
