Levels of serological markers of hepatitis B virus in Tibetan college students and their relationship with HBV-DNA loads
10.3760/cma.j.cn341190-20240129-00128
- VernacularTitle:藏族大学生乙型肝炎血清学标志物水平及其与HBV-DNA载量的关系研究
- Author:
Fen GAO
1
;
Qu CI
;
Xiaokang HAO
;
Yuhe WANG
;
Xin LIU
;
Xiaojie ZHAO
;
Tiantian DU
;
Jiajia XUE
;
Na HE
;
Juan ZHOU
Author Information
1. 西藏民族大学附属医院检验科，咸阳 712082
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Epidemiologic studies;
Hepatitis B surface antigens;
Hepatitis B antibodies;
Deoxyribonucleases
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(1):60-64
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the detection status of serological markers for hepatitis B virus (HBV) among Tibetan college students and their relationship with HBV- deoxyribonucleic acid (DNA) load.Methods:A cross-sectional study was carried out to retrospectively analyze data from 1 514 Tibetan college students who visited the Affiliated Hospital of Xizang Minzu University for consultations or health examinations between June 1, 2021 and June 1, 2022. The prevalence of HBV infection among these students was analyzed, the primary epidemiological patterns of HBV markers were identified, and their relationship with HBV-DNA load was determined.Results:The positive rate of hepatitis B surface antigen (HBsAg) among the 1 514 Tibetan college students was 6.7% (101/1 514), while the positive rate for Hepatitis B surface antibody (HBsAb) was 42.2% (639/1 514). The primary serological pattern of HBV infection consisted of positive results for HBsAg, HBeAg, and HBcAb, which accounted for 48.5% of cases. This pattern showed significantly higher rates of HBV-DNA positivity and elevated viral load compared with other serological patterns ( χ2 = 8.70, P < 0.05). Conclusions:The HBV infection rate among Tibetan college students is 6.7%. The primary infection pattern is characterized by positive tests for HBsAg, HBeAg, and HBcAb, with an HBV-DNA positivity rate as high as 87.0% and elevated viral loads.
