Demographic characteristics of positive syphilis screening test results in unpaid blood donors in Wenzhou of Zhejiang Province and recall testing for false positive donors
10.3760/cma.j.cn341190-20240207-00163
- VernacularTitle:浙江省温州地区无偿献血者梅毒筛查试验阳性人口学特征分析及假阳性献血者召回检测
- Author:
Yaya WU
1
;
Feng ZHANG
1
;
Jie YANG
1
;
Xiaoyan CHEN
1
Author Information
1. 温州市中心血站质量管理科 温州市输血医学重点实验室，温州 325000
- Publication Type:Journal Article
- Keywords:
Blood donors;
Syphilis serodiagnosis;
False positive reactions;
Sex factors;
Age factors
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the demographic characteristics of positive syphilis screening test results among unpaid blood donors in Wenzhou and to provide a theoretical basis for recalling donors who have received false positive results in their syphilis screening tests.Methods:A retrospective study was conducted on the demographic characteristics of 746 unpaid blood donors in Wenzhou who tested positive for syphilis from March 2020 to September 2022. Donors with positive single-test results received targeted notifications, health inquiries, and general examinations. With their consent, these donors were allowed to re-enter the blood donation process.Results:A total of 296 898 blood donor samples were tested, resulting in the identification of 746 positive cases of syphilis antibodies, yielding a positivity rate of 0.3%. Among the positive cases, most were males aged between 35 and 45 years, with blood types A and O. They generally had an education level of junior high school or lower and were primarily first-time donors. Specifically, males accounted for 53.6% of the positive cases, while individuals aged 35 to 45 years made up 34.0% of the positive cases. Blood types A and O comprised 30.2% and 36.9% of the positive cases, respectively. Additionally, individuals with an education level of junior high school or below accounted for 43.7% of the positive cases, and first-time donors constituted 81.6%. A total of 14 cases were recalled, of which 11 were successfully contacted. Among the cases that underwent testing with the enzyme-linked immunosorbent assay, 85.7% (12/14) tested negative for syphilis antibodies, resulting in a recall success rate of 78.6% (11/14).Conclusions:To prevent the transmission of syphilis through blood transfusions, blood donation centers should prioritize recruiting donors from low-risk populations and encourage regular blood donation. Furthermore, these centers should implement a comprehensive and effective recall program to reduce the loss of qualified blood donors and enhance blood safety.
