Research progress of progesterone-induced blocking factor in pregnancy
10.3760/cma.j.cn101441-20250321-00136
- VernacularTitle:孕酮诱导封闭因子在妊娠方面的研究进展
- Author:
Xiaohui LIU
1
;
Man LI
1
;
Lixia HE
1
;
Jun YAO
1
Author Information
1. 桂林医学院附属医院生殖医学中心，桂林 541001
- Publication Type:Journal Article
- Keywords:
Progesterone-induced blocking factor;
Endometrial receptivity;
Pregnancy;
Immune balance
- From:
Chinese Journal of Reproduction and Contraception
2025;45(9):960-966
- CountryChina
- Language:Chinese
-
Abstract:
Progesterone-induced blocking factor (PIBF) is an immunomodulatory protein secreted by maternal activated lymphocytes, decidual cells and trophoblast cells. It mainly maintains the immune balance at the maternal-fetal interface by inhibiting natural killer cell activity and inducing type 2 helper T cell immune response. In addition, PIBF, as the core effector molecule downstream of progesterone signaling pathway, is closely related to endometrial proliferation and decidualization, trophoblast cell syncytialization and placental vascularization. PIBF plays an important role in pregnancy by regulating maternal-fetal interface immune balance and endometrial receptivity. In this article, we reviewed the issues related to PIBF and pregnancy, with the aim of providing better guidance for clinical work.
