Relationship between killer cell immunoglobulin like receptor genotype and haplotype with dry eye diseas
10.3969/j.issn.1000-484X.2025.05.029
- VernacularTitle:杀伤细胞免疫球蛋白样受体基因型和单倍型与干眼病的关系
- Author:
Yunxia LIU
1
;
Qun WANG
1
;
Jing HUANG
1
;
Liangzheng YANG
1
;
Jie PENG
1
;
Guifang REN
1
Author Information
1. 济南市第四人民医院,济南 250033
- Publication Type:Journal Article
- Keywords:
Killer cell immunoglobulin-like receptor;
Genotype;
Haplotype;
Dry eye disease
- From:
Chinese Journal of Immunology
2025;41(5):1197-1201
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether killer immunoglobulin-like receptor(KIR)genotypes and haplotype are associated with the dry eye disease(DED)in a Chinese Han population.Methods:Polymerase chain reaction with sequence-specific primers(PCR-SSP)method was used to genotype KIR genes in 106 DED patients and 220 healthy controls.Results:A total of 23 KIR geno-types were found in DED patients and healthy controls,including 10 newly discovered KIR genotypes.The genotype G and haplotype 4 were associated with respectively increased risk of DED(P=0.025,P=0.004);while the haplotype 2 appeared to have an inverse asso-ciation with the disease(P=0.016).The frequency of KIR genotype B/B in DED patients was also significantly higher than that in con-trol group(P=0.027).KIR haplotype A and B had distinctive centromeric(Cen)and telomeric(Tel)gene-content motifs,and the Cen-B/B was associated with increased risk of DED(P=0.037).Conclusion:There may be an association between KIR genotype and hap-loid type with DED in Han population.
