Effects of Yiqi Tongluo Decoction combined with acupuncture on hemorheology and neurological function in patients with ischemic stroke due to qi deficiency and blood stasis syndrome
10.3760/cma.j.cn341190-20240702-00852
- VernacularTitle:益气通络汤联合针灸治疗气虚血瘀证缺血性脑卒中对患者血液流变学、神经功能的影响
- Author:
Yanbin YAN
1
;
Wenwen LIU
Author Information
1. 北京中医药大学孙思邈医院康复医学科，铜川 727000
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain infarction;
Drugs,Chinese herbal;
Acupuncture points;
Moxibustion;
Blood viscosity;
Glutathione peroxidase;
Phosphopyruvate hydratase;
High mobi
- From:
Chinese Journal of Primary Medicine and Pharmacy
2025;32(1):47-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effects of Yiqi Tongluo Decoction combined with acupuncture on hemorheology and neurological function in patients with ischemic stroke due to qi deficiency and blood stasis syndrome. Methods:This study was designed as a prospective study. It included 120 patients with ischemic stroke due to qi deficiency and blood stasis syndrome, all of whom received treatment at Sun Simiao Hospital, Beijing University of Chinese Medicine between April 2021 and May 2023. The patients were randomly assigned to either an observation group ( n = 60) or a control group ( n = 60) using a random number table method. Both groups received standard conventional treatment. The control group received acupuncture, while the observation group was treated with both acupuncture and Yiqi Tongluo Decoction. Neurological function deficits were evaluated for both groups before and after treatment, and hemorheological indices, antioxidant enzyme levels, and markers of brain injury were measured to evaluate treatment efficacy. Results:After treatment, the scores on the China Stroke Scale and the National Institutes of Health Stroke Scale in the observation group were (11.37 ± 1.25) points and (6.18 ± 0.73) points, respectively, which were significantly lower than those in the control group [ (15.31 ± 1.59) points, (8.31 ± 0.92) points, t = 15.09,14.05, both P < 0.001]. After treatment, the plasma and whole blood viscosity levels in the observation group were (1.41 ± 0.15) mPa·s and (9.05 ± 1.01) mPa·s, respectively, which were significantly lower than those in the control group [(1.75 ± 0.18) mPa·s, (10.28 ± 1.14) mPa·s, t = 11.24,6.26, both P < 0.001]. The levels of serum catalase and glutathione peroxidase in the observation group were (160.85 ± 17.11) U/L and (40.31 ± 4.08) U/L, respectively, which were significantly higher than those in the control group [(139.64 ± 14.52) U/L, (34.85 ± 3.61) U/L, t = -7.32,-7.76, both P < 0.001]. The serum levels of high mobility group protein-1 and neuron-specific enolase in the observation group were (4.25 ± 0.43) μg/L and (18.57±1.92) μg/L, respectively, which were significantly lower than those in the control group [(5.84±0.61) μg/L, (22.63±2.31) μg/L, t = 10.47, 16.50, both P < 0.001]. The overall response rate in the observation group was significantly higher than that in the control group ( χ2 = 6.51, P < 0.05). Conclusions:Yiqi Tongluo Decoction combined with acupuncture has demonstrated significant benefits in treating patients with ischemic stroke due to qi deficiency and blood stasis syndrome. This approach can enhance hemorheology, increase antioxidant enzyme levels, minimize brain tissue damage, and improve neurological function in patients.
