Clinical effect of combining astragalus membranaceus with mifepristone on endometriosis of cold coagulation stasis type and its influence on patients' immune function and inflammatory factors
10.3969/j.issn.1000-484X.2025.05.027
- VernacularTitle:黄芪与米非司酮结合对寒凝血瘀型子宫内膜异位症的临床效果及对患者免疫功能、炎症因子的影响
- Author:
Yueming ZHAO
1
;
Xia JI
1
;
Yanqing LI
1
;
Xiaoli LIU
1
;
Yanshe SHAO
1
Author Information
1. 河南省中医院妇科,郑州 450000
- Publication Type:Journal Article
- Keywords:
Endometriosis;
Astragalus;
Mifepristone;
Immune function;
Inflammatory factor
- From:
Chinese Journal of Immunology
2025;41(5):1186-1191
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The clinical effect of astragalus membranaceus and mifepristone on endometriosis and its effects on patiens' immune function and inflammatory factors were analyzed.Methods:A total of 86 patients with cold-coagulation and blood-stasis endometriosis treated in Henan Provincial Hospital of Traditional Chinese from October 2021 to October 2022 were selected and divided into mifepristone group(41 cases)and astragalus and mifepristone combination group(45 cases)by random number table method.Evaluated the TCM syndrome score level of patients before and after treatment;detection of luteinizing hormone(LH),follicle-stimu-lating hormone(FSH),estradiol(E2),anti-mullerian hormon(AMH),hypersensitive C-reactive egg(hs-CRP),IL-6,IL-8,TNF-α,CD4+T,CD8+T,CD4+T/CD8+T and the number of Antral Follicle Coun(AFC)were compared between the two groups.Results:After treatment,the levels of abdominal pain,dysphoria,cold shape and limb cold score,LH,FSH,E2,hs-CRP,IL-6,IL-8,TNF-α,CD8+T and AMH in combination group were lower than those in mifepristone group(P<0.05).CD4+T,CD4+T/CD8T+and AFC were higher than those in mifepristone group(P<0.05).The total effective rate of the combination group after treatment was higher than that of the mifepristone group(P<0.05).Conclusion:By combining astragalus and mifepristone,the traditional Chinese medicine syndrome scores of patients with cold coagulation and blood stasis type endometriosis are reduced,sexual hormones and ovarian function are improved,inflammatory reactions are alleviated,and the clinical treatment effect is remarkable.
