Nerve growth factor concentration in follicular fluid associated with abnormal menstrual cycle in patients with PCOS
- VernacularTitle:卵泡液神经生长因子浓度与多囊卵巢综合征不孕患者月经周期紊乱相关性研究
- Author:
Yanru LOU
1
;
Tian TIAN
1
;
Jianfei GONG
1
;
Jian HAN
1
;
Mengyuan TIAN
1
;
Xiaoqing HE
1
;
Xiaolin XU
1
;
Jinze YANG
1
;
Chenhong LIU
1
;
Jialin LI
1
;
Ping LIU
1
;
Rong LI
1
;
Rui YANG
1
;
Jie YAN
1
;
Jie QIAO
1
Author Information
- Publication Type:Journal Article
- Keywords: Nerve growth factor; Polycystic ovary syndrome; Ovulation disorder; Menstrual cycle
- From: Chinese Journal of Reproduction and Contraception 2025;45(11):1106-1112
- CountryChina
- Language:Chinese
- Abstract: Objective:To investigate the relationship between nerve growth factor (NGF) concentration in follicular fluid and abnormal menstrual cycle in infertile patients with polycystic ovary syndrome (PCOS).Methods:A retrospective cohort study was conducted on 100 infertile patients with PCOS who underwent in vitro fertilization and embryo transfer (IVF-ET) at Department of Obstetrics and Gynecology, Peking University Third Hospital from March 2017 to June 2019. For comparison, the 100 patients with PCOS were divided into low NGF group ( n=50) and high NGF group ( n=50) based on the median NGF concentration (1 644.03 ng/L) in follicular fluid. Baseline characteristics, menstrual status and clinical outcomes of assisted reproductive technology were compared. We performed multiple linear regression analysis to examine the effect of NGF in follicular fluid on menstrual cycle length for multivariate analysis. Results:1) PCOS patients in the low NGF group had significantly higher body mass index [(27.24±5.17) kg/m 2] and white blood cell count [7.31(5.99, 8.43)×10 9/L ] than those in the high NGF group [(25.03±4.46) kg/m 2, P=0.024; 5.95(5.08,7.01)×10 9/L, P=0.001], while high-density lipoprotein cholesterol [1.15 (0.98, 1.36) mmol/L] and basic follicle-stimulating hormone level [6.51 (5.10,7.95) U/L] in the low NGF group were significantly lower than those in the high NGF group [1.36 (1.09,1.52) mmol/L, P=0.039;6.51 (5.10,7.95)U/L, P=0.040]. 2) PCOS patients in the low NGF group had significantly higher menstrual cycle length [60.00 (35.00, 180.00) d] than the high NGF group [32.50 (27.00,67.50) d, P=0.001]. 3) Multiple linear regression analysis revealed that after adjustment for body mass index, age, infertility duration, infertility type, and glucose and lipid metabolic parameters, the NGF concentration in the follicular fluid independently and negatively correlated with menstrual cycle length ( P<0.05). 4) The NGF concentration in follicular fluid was not correlated with assisted reproductive outcomes. Conclusion:NGF concentration in follicular fluid is closely related to the degree of menstrual cycle abnormalities in patients with PCOS.
